Dihydrofolate reductase activity in the erythroblasts of patients with 5q- syndrome

R. Nano, R. Invernizzi, A. Pecci, M. Civallero, G. Gerzeli

Research output: Contribution to journalArticle

Abstract

We demonstrated a qualitative and quantitative cytochemical decrease of dihydrofolate reductase activity in the erythroblasts of 4 patients with the 5q- syndrome compared with 10 normal controls and 8 patients with myelodysplastic diseases. We hypothesized that this enzyme abnormality could be important for understanding the pathogenesis of the syndrome.

Original languageEnglish
Pages (from-to)765-784
Number of pages20
JournalHaematologica
Volume85
Issue number7
Publication statusPublished - 2000

Keywords

  • 5q-syndrome
  • Cytophotometric analysis
  • Dihydrofolate reductase
  • Myelodysplastic syndrome

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Nano, R., Invernizzi, R., Pecci, A., Civallero, M., & Gerzeli, G. (2000). Dihydrofolate reductase activity in the erythroblasts of patients with 5q- syndrome. Haematologica, 85(7), 765-784.