Dilated and failing cardiomyopathy in bradykinin B2 receptor knockout mice

Costanza Emanueli, Roberta Maestri, Domenico Corradi, Roberta Marchione, Alessandra Minasi, Maria Grazia Tozzi, Maria Bonaria Salis, Stefania Straino, Maurizio C. Capogrossi, Giorgio Olivetti, Paolo Madeddu

Research output: Contribution to journalArticle

Abstract

Background - The activation of B2 receptors by kinins could exert cardioprotective effects in myocardial ischemia and heart failure. Methods and Results - To test whether the absence of bradykinin B2 receptors may affect cardiac structure and function, we examined the developmental changes in blood pressure (BP), heart rate, and heart morphology of bradykinin B2 receptor gene knockout (B2(-/-)), heterozygous (B2(+/-)), and wild-type (B2(+/+)) mice. The BP of B2(-/-) mice, which was still normal at 50 days of age, gradually increased, reaching a plateau at 6 months (136±3 versus 109±1 mm Hg in B2(+/+), P2(+/-) mice, BP elevation was delayed. At 40 days, the heart rate was higher (P2(-/-) and B2(+/-) than in B2(+/+) mice, whereas the left ventricular (LV) weight and chamber volume were similar among groups. Thereafter, the LV growth rate of B2(-/-) and B2(+/-) mice was accelerated, leading at 360 days to a LV weight-to-body weight ratio that was 9% and 17% higher, respectively, than that of B2(+/+) mice. In B2(-/-) mice, hypertrophy was associated with a marked chamber dilatation (42% larger than that of B2(+/+) mice), an elevation in LV end-diastolic pressure (25±3 versus 5±1 mm Hg in B2(+/+) mice, p2 receptor leads to hypertension, LV remodeling, and functional impairment, implying that kinins are essential for the functional and structural preservation of the heart.

Original languageEnglish
Pages (from-to)2359-2365
Number of pages7
JournalCirculation
Volume100
Issue number23
Publication statusPublished - Dec 7 1999

Keywords

  • Angiotensin
  • Blood pressure
  • Bradykinin
  • Genes
  • Heart failure
  • Hypertrophy
  • Myocardium

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Dilated and failing cardiomyopathy in bradykinin B2 receptor knockout mice'. Together they form a unique fingerprint.

  • Cite this

    Emanueli, C., Maestri, R., Corradi, D., Marchione, R., Minasi, A., Tozzi, M. G., Salis, M. B., Straino, S., Capogrossi, M. C., Olivetti, G., & Madeddu, P. (1999). Dilated and failing cardiomyopathy in bradykinin B2 receptor knockout mice. Circulation, 100(23), 2359-2365.