Dimerizable redox-sensitive triazine-based cationic lipids for in vitro gene delivery

Gabriele Candiani, Massimo Frigerio, Fiorenza Viani, Chiara Verpelli, Carlo Sala, Luca Chiamenti, Nadia Zaffaroni, Marco Folini, Monica Sani, Walter Panzeri, Matteo Zanda

Research output: Contribution to journalArticle

Abstract

(Chemical Equation Presented) The "Trojan Horse" trick works again. Conceptually new melamine-based cationic lipids show excellent transfection efficiency and low cytotoxicity in delivering a DNA plasmid payload to different types of cells, deceiving the natural mechanism of defense toward exogeneous DNA.

Original languageEnglish
Pages (from-to)292-296
Number of pages5
JournalChemMedChem
Volume2
Issue number3
DOIs
Publication statusPublished - Mar 12 2007

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Keywords

  • Amphiphiles
  • DNA
  • Thiols
  • Transfection
  • Triazines

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry
  • Molecular Medicine

Cite this

Candiani, G., Frigerio, M., Viani, F., Verpelli, C., Sala, C., Chiamenti, L., Zaffaroni, N., Folini, M., Sani, M., Panzeri, W., & Zanda, M. (2007). Dimerizable redox-sensitive triazine-based cationic lipids for in vitro gene delivery. ChemMedChem, 2(3), 292-296. https://doi.org/10.1002/cmdc.200600267