Dimethylarginines in complicated type 1 diabetes: Roles of insulin, glucose, and oxidative stress

Giuliana Cighetti, Isabella Fermo, Caroline S. Aman, Monica Ferraroni, Antonio Secchi, Paolo Fiorina, Rita Paroni

Research output: Contribution to journalArticle

Abstract

To investigate the roles of insulin, glucose, and oxidative stress on plasma asymmetric and symmetric dimethylarginine (ADMA, SDMA) levels in complicated diabetes, we studied patients with type 1 diabetes (T1D; n = 20), T1D + end-stage renal disease under hemodialysis (T1D + ESRD; n = 12), T1D + ESRD who received kidney transplant (KD; n = 16), and T1D + ESRD who received kidney-pancreas transplant (KP; n = 20) and healthy controls (n = 50). Levels of ADMA, SDMA, and free and total malondialdehyde (MDA) were increased in all patients, with the highest rises for SDMA and free MDA in T1D + ESRD. In KP, the normalized glycemia contributes to the recovery of ADMA, SDMA, and MDA levels toward normal values. From the covariance analyses, both glucose and insulin relate significantly to ADMA in T1D + ESRD (β = + 0.004, β = - 0.038, respectively) and in KP (β = + 0.032, β = + 0.032, respectively). Creatinine clearance and insulin relate to SDMA in all patient groups (β = - 0.006). Our results provide evidence for the effect of kidney-pancreas transplant on the recovery of ADMA, SDMA, and indexes of oxidative stress toward normal values. Only free MDA allows one to discriminate the magnitude of the oxidative status, as increased total MDA could also be attributable to a reduced renal function.

Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalFree Radical Biology and Medicine
Volume47
Issue number3
DOIs
Publication statusPublished - Aug 1 2009

Fingerprint

Space division multiple access
Oxidative stress
Medical problems
Type 1 Diabetes Mellitus
Chronic Kidney Failure
Malondialdehyde
Oxidative Stress
Insulin
Glucose
Transplants
Kidney
Pancreas
Reference Values
Recovery
Renal Dialysis
dimethylarginine
Creatinine
Plasmas

Keywords

  • Dimethylarginines
  • Free radicals
  • Glucose
  • Insulin
  • Oxidative stress
  • Type 1 diabetes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

Cite this

Dimethylarginines in complicated type 1 diabetes : Roles of insulin, glucose, and oxidative stress. / Cighetti, Giuliana; Fermo, Isabella; Aman, Caroline S.; Ferraroni, Monica; Secchi, Antonio; Fiorina, Paolo; Paroni, Rita.

In: Free Radical Biology and Medicine, Vol. 47, No. 3, 01.08.2009, p. 307-311.

Research output: Contribution to journalArticle

Cighetti, Giuliana ; Fermo, Isabella ; Aman, Caroline S. ; Ferraroni, Monica ; Secchi, Antonio ; Fiorina, Paolo ; Paroni, Rita. / Dimethylarginines in complicated type 1 diabetes : Roles of insulin, glucose, and oxidative stress. In: Free Radical Biology and Medicine. 2009 ; Vol. 47, No. 3. pp. 307-311.
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