The early effects of TCDD exposure in the population involved in the Seveso, Italy, incident in 1976 have been examined in numerous studies. Chloracne was the only effect established beyond any doubt. The long-term consequences have been investigated with mortality and cancer incidence studies. The mortality study, 1976-1986, showed an increased cardiovascular risk in the early period after the accident, possibly related to the stressful post-disaster experience. Cancer incidence findings in the same period suggested increased risks for hepatobiliary cancer, neoplasms of the lymphatic and hematopoietic tissue, and soft tissue sarcoma. The extension of the mortality study to 1991, confirmed the increased cardiovascular mortality and suggested an elevated risk for diabetes. An increased mortality from digestive tract cancers and lymphatic and hematopoietic neoplasms was also visible. Results of previous experimental and epidemiological studies corroborate the hypothesis that the observed excesses are associated with dioxin exposure.
|Publication status||Published - Apr 1997|
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