Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted β2,3-Diarylamino Acid and l -Alanine as Candidates for Biomedical Applications

Andrea Bonetti, Sara Pellegrino, Priyadip Das, Sivan Yuran, Raffaella Bucci, Nicola Ferri, Fiorella Meneghetti, Carlo Castellano, Meital Reches, Maria Luisa Gelmi

Research output: Contribution to journalArticle

Abstract

The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β2,3-diarylamino acid and l-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.

Original languageEnglish
Pages (from-to)4468-4471
Number of pages4
JournalOrganic Letters
Volume17
Issue number18
DOIs
Publication statusPublished - Sep 18 2015

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry
  • Medicine(all)

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    Bonetti, A., Pellegrino, S., Das, P., Yuran, S., Bucci, R., Ferri, N., Meneghetti, F., Castellano, C., Reches, M., & Gelmi, M. L. (2015). Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted β2,3-Diarylamino Acid and l -Alanine as Candidates for Biomedical Applications. Organic Letters, 17(18), 4468-4471. https://doi.org/10.1021/acs.orglett.5b02132