Diplopia as isolated presentation of varicella zoster central nervous system reactivation

Cosmo Del Borgo, Valeria Belvisi, Maria Beatrice Valli, Antonio Currà, Irene Pozzetto, Massimiliano Sepe, Claudio Maria Mastroianni

Research output: Contribution to journalArticle

Abstract

Here, we report a patient who developed diplopia secondary to a right cranial nerve III and IV palsy, as well as fever and headache. Cerebrospinal fluid analysis (CSF) showed high varicella-zoster virus (VZV)-DNA viral load (>300,000,000 copies/ml). VZV antibodies in CSF was ≥1:16. Diagnosis of neurological reactivation of VZV infection was made without the presence of characteristic vesicular rash. Quantitative real-time PCR for VZV and intrathecal dosage of VZV IgM and IgG should be performed in cases suspected for viral encephalitis and also in all patients with not otherwise attributable cranial nerve lesions.

Original languageEnglish
Pages (from-to)621-624
Number of pages4
JournalJournal of NeuroVirology
Volume23
Issue number4
DOIs
Publication statusPublished - Aug 1 2017

Keywords

  • Diplopia
  • Varicella-zoster virus (VZV) reactivation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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  • Cite this

    Del Borgo, C., Belvisi, V., Valli, M. B., Currà, A., Pozzetto, I., Sepe, M., & Mastroianni, C. M. (2017). Diplopia as isolated presentation of varicella zoster central nervous system reactivation. Journal of NeuroVirology, 23(4), 621-624. https://doi.org/10.1007/s13365-017-0534-z