Abstract
Capillary zone electrophoresis (CZE) was used for the enantiomeric separation of (R,S)-tiaprofenic acid ([R,S]-Tia) in a pharmaceutical formulation employing an acetate buffer at pH 4.5 and 2,3,6-tri-O-methyl-beta-cyclodextrin (tri-OMe-beta-CD) as the chiral selector. The effect of the concentration of trimethylated-beta-cyclodextrin in the presence of carboxymethylated-beta-cyclodextrin (CM-beta-CD) on enantiomeric resolution of (R,S)-Tia and (R,S)-5-benzoyl-alpha-methyl-3-thiopheneacetic acid (3-isomer of tiaprofenic acid, 3-Tia) was investigated at pH 4, 4.5, and 5.
| Original language | English |
|---|---|
| Pages (from-to) | 213-217 |
| Number of pages | 5 |
| Journal | Journal of Capillary Electrophoresis and Microchip Technology |
| Volume | 2 |
| Issue number | 5 |
| Publication status | Published - Sep 1995 |
ASJC Scopus subject areas
- Electrochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
Fingerprint Dive into the research topics of 'Direct chiral resolution of tiaprofenic acid in pharmaceutical formulations by capillary zone electrophoresis using cyclodextrins as chiral selector.'. Together they form a unique fingerprint.
Cite this
Aturki, Z., Camera, E., La Torre, F., & Fanali, S. (1995). Direct chiral resolution of tiaprofenic acid in pharmaceutical formulations by capillary zone electrophoresis using cyclodextrins as chiral selector. Journal of Capillary Electrophoresis and Microchip Technology, 2(5), 213-217.