Direct chiral resolution of tiaprofenic acid in pharmaceutical formulations by capillary zone electrophoresis using cyclodextrins as chiral selector.

Z. Aturki, E. Camera, F. La Torre, S. Fanali

Research output: Contribution to journalArticle

Abstract

Capillary zone electrophoresis (CZE) was used for the enantiomeric separation of (R,S)-tiaprofenic acid ([R,S]-Tia) in a pharmaceutical formulation employing an acetate buffer at pH 4.5 and 2,3,6-tri-O-methyl-beta-cyclodextrin (tri-OMe-beta-CD) as the chiral selector. The effect of the concentration of trimethylated-beta-cyclodextrin in the presence of carboxymethylated-beta-cyclodextrin (CM-beta-CD) on enantiomeric resolution of (R,S)-Tia and (R,S)-5-benzoyl-alpha-methyl-3-thiopheneacetic acid (3-isomer of tiaprofenic acid, 3-Tia) was investigated at pH 4, 4.5, and 5.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalJournal of Capillary Electrophoresis and Microchip Technology
Volume2
Issue number5
Publication statusPublished - Sep 1995

ASJC Scopus subject areas

  • Electrochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

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