Direct chiral resolution of tiaprofenic acid in pharmaceutical formulations by capillary zone electrophoresis using cyclodextrins as chiral selector.

Z. Aturki, E. Camera, F. La Torre, S. Fanali

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Capillary zone electrophoresis (CZE) was used for the enantiomeric separation of (R,S)-tiaprofenic acid ([R,S]-Tia) in a pharmaceutical formulation employing an acetate buffer at pH 4.5 and 2,3,6-tri-O-methyl-beta-cyclodextrin (tri-OMe-beta-CD) as the chiral selector. The effect of the concentration of trimethylated-beta-cyclodextrin in the presence of carboxymethylated-beta-cyclodextrin (CM-beta-CD) on enantiomeric resolution of (R,S)-Tia and (R,S)-5-benzoyl-alpha-methyl-3-thiopheneacetic acid (3-isomer of tiaprofenic acid, 3-Tia) was investigated at pH 4, 4.5, and 5.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalJournal of Capillary Electrophoresis and Microchip Technology
Volume2
Issue number5
Publication statusPublished - Sep 1995

Fingerprint

Drug Compounding
tri-O-methyl-beta-cyclodextrin
Cyclodextrins
Capillary Electrophoresis
Electrophoresis
Drug products
Acids
Isomers
Pharmaceutical Preparations
Buffers
Acetates
tiaprofenic acid
betadex

ASJC Scopus subject areas

  • Electrochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

@article{a410d4404e254a91b453bceaf968c4e1,
title = "Direct chiral resolution of tiaprofenic acid in pharmaceutical formulations by capillary zone electrophoresis using cyclodextrins as chiral selector.",
abstract = "Capillary zone electrophoresis (CZE) was used for the enantiomeric separation of (R,S)-tiaprofenic acid ([R,S]-Tia) in a pharmaceutical formulation employing an acetate buffer at pH 4.5 and 2,3,6-tri-O-methyl-beta-cyclodextrin (tri-OMe-beta-CD) as the chiral selector. The effect of the concentration of trimethylated-beta-cyclodextrin in the presence of carboxymethylated-beta-cyclodextrin (CM-beta-CD) on enantiomeric resolution of (R,S)-Tia and (R,S)-5-benzoyl-alpha-methyl-3-thiopheneacetic acid (3-isomer of tiaprofenic acid, 3-Tia) was investigated at pH 4, 4.5, and 5.",
author = "Z. Aturki and E. Camera and {La Torre}, F. and S. Fanali",
year = "1995",
month = "9",
language = "English",
volume = "2",
pages = "213--217",
journal = "Journal of Capillary Electrophoresis and Microchip Technology",
issn = "1079-5383",
publisher = "International Scientific Communications Inc.",
number = "5",

}

TY - JOUR

T1 - Direct chiral resolution of tiaprofenic acid in pharmaceutical formulations by capillary zone electrophoresis using cyclodextrins as chiral selector.

AU - Aturki, Z.

AU - Camera, E.

AU - La Torre, F.

AU - Fanali, S.

PY - 1995/9

Y1 - 1995/9

N2 - Capillary zone electrophoresis (CZE) was used for the enantiomeric separation of (R,S)-tiaprofenic acid ([R,S]-Tia) in a pharmaceutical formulation employing an acetate buffer at pH 4.5 and 2,3,6-tri-O-methyl-beta-cyclodextrin (tri-OMe-beta-CD) as the chiral selector. The effect of the concentration of trimethylated-beta-cyclodextrin in the presence of carboxymethylated-beta-cyclodextrin (CM-beta-CD) on enantiomeric resolution of (R,S)-Tia and (R,S)-5-benzoyl-alpha-methyl-3-thiopheneacetic acid (3-isomer of tiaprofenic acid, 3-Tia) was investigated at pH 4, 4.5, and 5.

AB - Capillary zone electrophoresis (CZE) was used for the enantiomeric separation of (R,S)-tiaprofenic acid ([R,S]-Tia) in a pharmaceutical formulation employing an acetate buffer at pH 4.5 and 2,3,6-tri-O-methyl-beta-cyclodextrin (tri-OMe-beta-CD) as the chiral selector. The effect of the concentration of trimethylated-beta-cyclodextrin in the presence of carboxymethylated-beta-cyclodextrin (CM-beta-CD) on enantiomeric resolution of (R,S)-Tia and (R,S)-5-benzoyl-alpha-methyl-3-thiopheneacetic acid (3-isomer of tiaprofenic acid, 3-Tia) was investigated at pH 4, 4.5, and 5.

UR - http://www.scopus.com/inward/record.url?scp=0029361981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029361981&partnerID=8YFLogxK

M3 - Article

VL - 2

SP - 213

EP - 217

JO - Journal of Capillary Electrophoresis and Microchip Technology

JF - Journal of Capillary Electrophoresis and Microchip Technology

SN - 1079-5383

IS - 5

ER -