Direct coronary vasodilator effects of intracoronary histamine administration in humans

Carlo Vigorito, Arturo Giordano, Lorenzo De Caprio, Dino Vitale, Nicola Ferrara, Bernardino Tuccillo, Nicola Maurea, Matteo Rispoli, Franco Rengo

Research output: Contribution to journalArticlepeer-review

Abstract

Histamine is widely present in human tissues and can be released by immunologic and nonimmunologic reactions. Although several direct cardiovascular effects of histamine have been demonstrated in humans, little is known about the direct effects of histamine on the human coronary circulation in vivo. Therefore, we investigated the changes in coronary hemodynamics induced by bolus intracoronary administration of 4 μg of histamine to 11 patients with angiographically normal coronary arteries under continuous monitoring of R-R interval from the electrocardiogram, arterial pressure (AP), and coronary sinus blood flow (CBF), measured by thermodilution. Immediately after the end of the intracoronary histamine bolus, with R-R interval and AP unchanged CBF increased from 144 ± 20 to 238 ± 27 ml/min (p <0.01) and coronary vascular resistance decreased from 0.7 ± 0.16 to 0.42 ± 0.1 mm Hg/ml/min (p <0.01). No change in coronary hemodynamics was observed after bolus intracoronary administration of physiologic saline. The effects of histamine on systemic hemodynamics consisted of a transient fall in AP and in R-R interval, starting after the onset of changes in coronary hemodynamics. These data show that histamine possesses a direct coronary vasodilator effect in humans, independent of the determinants of myocardial oxygen consumption.

Original languageEnglish
Pages (from-to)933-939
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume8
Issue number5
Publication statusPublished - 1986

Keywords

  • Coronary blood flow
  • Coronary hemodynamics
  • Histamine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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