Direct demonstration of the effects of repetitive transcranial magnetic stimulation on the excitability of the human motor cortex

V. Di Lazzaro, A. Oliviero, A. Berardelli, P. Mazzone, A. Insola, F. Pilato, E. Saturno, M. Dileone, P. Tonali, J. Rothwell

Research output: Contribution to journalArticle

Abstract

The effects of repetitive transcranial magnetic stimulation (rTMS; 20 stimuli at 5 Hz at 120% resting motor threshold intensity using a biphasic stimulus pulse) on the excitability of human motor cortex were investigated in two patients who had an electrode implanted into the cervical epidural space. The corticospinal D wave increased in amplitude with successive stimuli, and reached a maximum after three or five pulses. At this stage, the amplitude of the I waves was unchanged, but after a further 10 stimuli an additional I wave was recruited. Both effects were still evident 2 min after the end of the rTMS. The effects are compatible with a short-term increase in cortical excitability during suprathreshold rTMS.

Original languageEnglish
Pages (from-to)549-553
Number of pages5
JournalExperimental Brain Research
Volume144
Issue number4
DOIs
Publication statusPublished - 2002

Keywords

  • Motor cortex
  • Plasticity
  • RTMS
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

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    Di Lazzaro, V., Oliviero, A., Berardelli, A., Mazzone, P., Insola, A., Pilato, F., Saturno, E., Dileone, M., Tonali, P., & Rothwell, J. (2002). Direct demonstration of the effects of repetitive transcranial magnetic stimulation on the excitability of the human motor cortex. Experimental Brain Research, 144(4), 549-553. https://doi.org/10.1007/s00221-002-1106-9