TY - JOUR
T1 - Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation of profens
AU - Olšovská, Jana
AU - Flieger, Miroslav
AU - Bachechi, Fiorella
AU - Messina, Antonella
AU - Sinibaldi, Massimo
PY - 1999
Y1 - 1999
N2 - The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary phase was tested. X-ray analysis of crystals of the chiral selector and its complexes with naproxen allowed a deeper insight into the enantiodiscriminative process. The column stability and reproducibility, and the potential of the packing for semipreparative scale separations were also determined. A method for determining flobufen enantiomers and metabolites in plasma samples is described.
AB - The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary phase was tested. X-ray analysis of crystals of the chiral selector and its complexes with naproxen allowed a deeper insight into the enantiodiscriminative process. The column stability and reproducibility, and the potential of the packing for semipreparative scale separations were also determined. A method for determining flobufen enantiomers and metabolites in plasma samples is described.
KW - Chiral recognition mechanism
KW - Ergot alkaloid-based stationary phases
KW - HPLC enantioseparation
KW - Non-steroidal anti-inflammatory drugs (NSAIDs)
KW - Plasma
KW - Semipreparative scale separation
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U2 - 10.1002/(SICI)1520-636X(1999)11:4<291::AID-CHIR6>3.0.CO;2-4
DO - 10.1002/(SICI)1520-636X(1999)11:4<291::AID-CHIR6>3.0.CO;2-4
M3 - Article
C2 - 10224656
AN - SCOPUS:0042241691
VL - 11
SP - 291
EP - 300
JO - Chirality
JF - Chirality
SN - 0899-0042
IS - 4
ER -