Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation of profens

Jana Olšovská, Miroslav Flieger, Fiorella Bachechi, Antonella Messina, Massimo Sinibaldi

Research output: Contribution to journalArticle

Abstract

The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary phase was tested. X-ray analysis of crystals of the chiral selector and its complexes with naproxen allowed a deeper insight into the enantiodiscriminative process. The column stability and reproducibility, and the potential of the packing for semipreparative scale separations were also determined. A method for determining flobufen enantiomers and metabolites in plasma samples is described.

Original languageEnglish
Pages (from-to)291-300
Number of pages10
JournalChirality
Volume11
Issue number4
DOIs
Publication statusPublished - 1999

Keywords

  • Chiral recognition mechanism
  • Ergot alkaloid-based stationary phases
  • HPLC enantioseparation
  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Plasma
  • Semipreparative scale separation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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