Abstract
The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary phase was tested. X-ray analysis of crystals of the chiral selector and its complexes with naproxen allowed a deeper insight into the enantiodiscriminative process. The column stability and reproducibility, and the potential of the packing for semipreparative scale separations were also determined. A method for determining flobufen enantiomers and metabolites in plasma samples is described.
| Original language | English |
|---|---|
| Pages (from-to) | 291-300 |
| Number of pages | 10 |
| Journal | Chirality |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1999 |
Keywords
- Chiral recognition mechanism
- Ergot alkaloid-based stationary phases
- HPLC enantioseparation
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Plasma
- Semipreparative scale separation
ASJC Scopus subject areas
- Analytical Chemistry
- Organic Chemistry
- Drug Discovery
- Pharmacology
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Olšovská, J., Flieger, M., Bachechi, F., Messina, A., & Sinibaldi, M. (1999). Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation of profens. Chirality, 11(4), 291-300. https://doi.org/10.1002/(SICI)1520-636X(1999)11:4<291::AID-CHIR6>3.0.CO;2-4