Direct resolution of optically active isomers on chiral packings containing ergoline skeletons. 5. Enantioseparation of amino acid derivatives

A. Messina, A. M. Girelli, M. Flieger, M. Sinibaldi, P. Sedmera, L. Cvak

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A new procedure for ergot alkaloid-based chiral stationary phase preparation is described. Synthesis is based on bonding the allyl derivative of terguride to mercaptopropylsilanized silica gel. The packing exhibits higher content of chiral selector, stability, reproducibility, and enantioselectivity toward amino acids compared to that previously studied. The chromatographic behavior of amino acids with different side chains and substituent groups is investigated in order to obtain a deeper insight into the enantiodiscriminative mechanism as well as to determine the limitations and strengths of terguride as a chiral selector for this class of compounds. A variety of factors, including mobile phase parameters such as pH, ionic strength, content and nature of organic modifier, and temperature, are examined.

Original languageEnglish
Pages (from-to)1191-1196
Number of pages6
JournalAnalytical Chemistry
Volume68
Issue number7
DOIs
Publication statusPublished - Apr 1 1996

Fingerprint

Ergolines
Isomers
Ergot Alkaloids
Derivatives
Amino Acids
Enantioselectivity
Silica Gel
Ionic strength
Temperature
dironyl

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Direct resolution of optically active isomers on chiral packings containing ergoline skeletons. 5. Enantioseparation of amino acid derivatives. / Messina, A.; Girelli, A. M.; Flieger, M.; Sinibaldi, M.; Sedmera, P.; Cvak, L.

In: Analytical Chemistry, Vol. 68, No. 7, 01.04.1996, p. 1191-1196.

Research output: Contribution to journalArticle

Messina, A. ; Girelli, A. M. ; Flieger, M. ; Sinibaldi, M. ; Sedmera, P. ; Cvak, L. / Direct resolution of optically active isomers on chiral packings containing ergoline skeletons. 5. Enantioseparation of amino acid derivatives. In: Analytical Chemistry. 1996 ; Vol. 68, No. 7. pp. 1191-1196.
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