Direct visualization of neo-vessel formation following peripheral injection of bone marrow derived CD34+ cells in experimental myocardial damage

M. M. Ciulla; S. Ferrero; U. Gianelli; R. Paliotti; F. Magrini; P. Braidotti

doi:10.1016/j.micron.2006.08.007

Direct visualization of neo-vessel formation following peripheral injection of bone marrow derived CD34+ cells in experimental myocardial damage

M. M. Ciulla, S. Ferrero, U. Gianelli, R. Paliotti, F. Magrini, P. Braidotti

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article

Abstract

The definitive fate of peripherally injected PKH26 labelled bone marrow mononuclear cells expressing the CD34+ antigen following experimental myocardial cryodamage in rats (n = 10) has been examined by direct visualization on photoconverted light and electron microscopy images. One week after the injection in each rat of about 150,000 CD34+ cells early stage PKH26+ vascular structures were localized in the infarcted areas, suggesting that a potential benefit of this therapeutic approach consists in the regeneration of the vasculature.

Original language	English
Pages (from-to)	321-322
Number of pages	2
Journal	Micron
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/j.micron.2006.08.007
Publication status	Published - Apr 2007

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Keywords

Angiogenesis
Bone marrow mononuclear cells
Electron microscopy
Myocardial cryoinjury
Photoconversion

ASJC Scopus subject areas

Cell Biology
Materials Science(all)
Instrumentation
Biotechnology

Cite this

Ciulla, M. M., Ferrero, S., Gianelli, U., Paliotti, R., Magrini, F., & Braidotti, P. (2007). Direct visualization of neo-vessel formation following peripheral injection of bone marrow derived CD34+ cells in experimental myocardial damage. Micron, 38(3), 321-322. https://doi.org/10.1016/j.micron.2006.08.007

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AU - Magrini, F.

AU - Braidotti, P.

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10.1016/j.micron.2006.08.007