Direct visualization of neo-vessel formation following peripheral injection of bone marrow derived CD34+ cells in experimental myocardial damage

M. M. Ciulla; S. Ferrero; U. Gianelli; R. Paliotti; F. Magrini; P. Braidotti

doi:10.1016/j.micron.2006.08.007

Direct visualization of neo-vessel formation following peripheral injection of bone marrow derived CD34+ cells in experimental myocardial damage

M. M. Ciulla, S. Ferrero, U. Gianelli, R. Paliotti, F. Magrini, P. Braidotti

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The definitive fate of peripherally injected PKH26 labelled bone marrow mononuclear cells expressing the CD34+ antigen following experimental myocardial cryodamage in rats (n = 10) has been examined by direct visualization on photoconverted light and electron microscopy images. One week after the injection in each rat of about 150,000 CD34+ cells early stage PKH26+ vascular structures were localized in the infarcted areas, suggesting that a potential benefit of this therapeutic approach consists in the regeneration of the vasculature.

Original language	English
Pages (from-to)	321-322
Number of pages	2
Journal	Micron
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/j.micron.2006.08.007
Publication status	Published - Apr 2007

Keywords

Angiogenesis
Bone marrow mononuclear cells
Electron microscopy
Myocardial cryoinjury
Photoconversion

ASJC Scopus subject areas

Cell Biology
Materials Science(all)
Instrumentation
Biotechnology

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title = "Direct visualization of neo-vessel formation following peripheral injection of bone marrow derived CD34+ cells in experimental myocardial damage",

abstract = "The definitive fate of peripherally injected PKH26 labelled bone marrow mononuclear cells expressing the CD34+ antigen following experimental myocardial cryodamage in rats (n = 10) has been examined by direct visualization on photoconverted light and electron microscopy images. One week after the injection in each rat of about 150,000 CD34+ cells early stage PKH26+ vascular structures were localized in the infarcted areas, suggesting that a potential benefit of this therapeutic approach consists in the regeneration of the vasculature.",

keywords = "Angiogenesis, Bone marrow mononuclear cells, Electron microscopy, Myocardial cryoinjury, Photoconversion",

author = "Ciulla, {M. M.} and S. Ferrero and U. Gianelli and R. Paliotti and F. Magrini and P. Braidotti",

year = "2007",

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T1 - Direct visualization of neo-vessel formation following peripheral injection of bone marrow derived CD34+ cells in experimental myocardial damage

AU - Ciulla, M. M.

AU - Ferrero, S.

AU - Gianelli, U.

AU - Paliotti, R.

AU - Magrini, F.

AU - Braidotti, P.

PY - 2007/4

Y1 - 2007/4

N2 - The definitive fate of peripherally injected PKH26 labelled bone marrow mononuclear cells expressing the CD34+ antigen following experimental myocardial cryodamage in rats (n = 10) has been examined by direct visualization on photoconverted light and electron microscopy images. One week after the injection in each rat of about 150,000 CD34+ cells early stage PKH26+ vascular structures were localized in the infarcted areas, suggesting that a potential benefit of this therapeutic approach consists in the regeneration of the vasculature.

AB - The definitive fate of peripherally injected PKH26 labelled bone marrow mononuclear cells expressing the CD34+ antigen following experimental myocardial cryodamage in rats (n = 10) has been examined by direct visualization on photoconverted light and electron microscopy images. One week after the injection in each rat of about 150,000 CD34+ cells early stage PKH26+ vascular structures were localized in the infarcted areas, suggesting that a potential benefit of this therapeutic approach consists in the regeneration of the vasculature.

KW - Angiogenesis

KW - Bone marrow mononuclear cells

KW - Electron microscopy

KW - Myocardial cryoinjury

KW - Photoconversion

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Direct visualization of neo-vessel formation following peripheral injection of bone marrow derived CD34+ cells in experimental myocardial damage

Abstract

Keywords

ASJC Scopus subject areas

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