Direct visualization of neo-vessel formation following peripheral injection of bone marrow derived CD34+ cells in experimental myocardial damage

M. M. Ciulla, S. Ferrero, U. Gianelli, R. Paliotti, F. Magrini, P. Braidotti

Research output: Contribution to journalArticle

Abstract

The definitive fate of peripherally injected PKH26 labelled bone marrow mononuclear cells expressing the CD34+ antigen following experimental myocardial cryodamage in rats (n = 10) has been examined by direct visualization on photoconverted light and electron microscopy images. One week after the injection in each rat of about 150,000 CD34+ cells early stage PKH26+ vascular structures were localized in the infarcted areas, suggesting that a potential benefit of this therapeutic approach consists in the regeneration of the vasculature.

Original languageEnglish
Pages (from-to)321-322
Number of pages2
JournalMicron
Volume38
Issue number3
DOIs
Publication statusPublished - Apr 2007

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Keywords

  • Angiogenesis
  • Bone marrow mononuclear cells
  • Electron microscopy
  • Myocardial cryoinjury
  • Photoconversion

ASJC Scopus subject areas

  • Cell Biology
  • Materials Science(all)
  • Instrumentation
  • Biotechnology

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