Directionality of EEG synchronization in Alzheimer's disease subjects

Claudio Babiloni; Raffaele Ferri; Giuliano Binetti; Fabrizio Vecchio; Giovanni B. Frisoni; Bartolo Lanuzza; Carlo Miniussi; Flavio Nobili; Guido Rodriguez; Francesco Rundo; Andrea Cassarino; Francesco Infarinato; Emanuele Cassetta; Serenella Salinari; Fabrizio Eusebi; Paolo M. Rossini

doi:10.1016/j.neurobiolaging.2007.05.007

Directionality of EEG synchronization in Alzheimer's disease subjects

Claudio Babiloni, Raffaele Ferri, Giuliano Binetti, Fabrizio Vecchio, Giovanni B. Frisoni, Bartolo Lanuzza, Carlo Miniussi, Flavio Nobili, Guido Rodriguez, Francesco Rundo, Andrea Cassarino, Francesco Infarinato, Emanuele Cassetta, Serenella Salinari, Fabrizio Eusebi, Paolo M. Rossini

Research output: Contribution to journal › Article › peer-review

Abstract

Is directionality of electroencephalographic (EEG) synchronization abnormal in amnesic mild cognitive impairment (MCI) and Alzheimer's disease (AD)? EEG data were recorded in 64 normal elderly (Nold), 69 amnesic MCI, and 73 mild AD subjects at rest condition (closed eyes). Direction of information flux within EEG functional coupling at electrode pairs was performed by directed transfer function (DTF) at delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10 Hz), alpha 2 (10-12 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz). Parietal to frontal direction of the information flux within EEG functional coupling was stronger in Nold than in MCI and/or AD subjects, namely for alpha and beta rhythms. In contrast, the directional flow within inter-hemispheric EEG functional coupling did not discriminate among the three groups. These results suggest that directionality of parieto-to-frontal EEG synchronization is abnormal not only in AD but also in amnesic MCI.

Original language	English
Pages (from-to)	93-102
Number of pages	10
Journal	Neurobiology of Aging
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2007.05.007
Publication status	Published - Jan 2009

Keywords

Directed transfer function (DTF)
Electroencephalography (EEG)
Mild Alzheimer's disease (mild AD)
Mild cognitive impairment (MCI)

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)
Ageing
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2007.05.007

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Babiloni, C., Ferri, R., Binetti, G., Vecchio, F., Frisoni, G. B., Lanuzza, B., Miniussi, C., Nobili, F., Rodriguez, G., Rundo, F., Cassarino, A., Infarinato, F., Cassetta, E., Salinari, S., Eusebi, F., & Rossini, P. M. (2009). Directionality of EEG synchronization in Alzheimer's disease subjects. Neurobiology of Aging, 30(1), 93-102. https://doi.org/10.1016/j.neurobiolaging.2007.05.007

Directionality of EEG synchronization in Alzheimer's disease subjects. / Babiloni, Claudio; Ferri, Raffaele ; Binetti, Giuliano ; Vecchio, Fabrizio; Frisoni, Giovanni B.; Lanuzza, Bartolo; Miniussi, Carlo; Nobili, Flavio; Rodriguez, Guido; Rundo, Francesco; Cassarino, Andrea; Infarinato, Francesco; Cassetta, Emanuele; Salinari, Serenella; Eusebi, Fabrizio; Rossini, Paolo M.

In: Neurobiology of Aging, Vol. 30, No. 1, 01.2009, p. 93-102.

Research output: Contribution to journal › Article › peer-review

Babiloni, C, Ferri, R , Binetti, G , Vecchio, F, Frisoni, GB, Lanuzza, B, Miniussi, C, Nobili, F, Rodriguez, G, Rundo, F, Cassarino, A, Infarinato, F, Cassetta, E, Salinari, S, Eusebi, F & Rossini, PM 2009, 'Directionality of EEG synchronization in Alzheimer's disease subjects', Neurobiology of Aging, vol. 30, no. 1, pp. 93-102. https://doi.org/10.1016/j.neurobiolaging.2007.05.007

Babiloni, Claudio ; Ferri, Raffaele ; Binetti, Giuliano ; Vecchio, Fabrizio ; Frisoni, Giovanni B. ; Lanuzza, Bartolo ; Miniussi, Carlo ; Nobili, Flavio ; Rodriguez, Guido ; Rundo, Francesco ; Cassarino, Andrea ; Infarinato, Francesco ; Cassetta, Emanuele ; Salinari, Serenella ; Eusebi, Fabrizio ; Rossini, Paolo M. / Directionality of EEG synchronization in Alzheimer's disease subjects. In: Neurobiology of Aging. 2009 ; Vol. 30, No. 1. pp. 93-102.

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abstract = "Is directionality of electroencephalographic (EEG) synchronization abnormal in amnesic mild cognitive impairment (MCI) and Alzheimer's disease (AD)? EEG data were recorded in 64 normal elderly (Nold), 69 amnesic MCI, and 73 mild AD subjects at rest condition (closed eyes). Direction of information flux within EEG functional coupling at electrode pairs was performed by directed transfer function (DTF) at delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10 Hz), alpha 2 (10-12 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz). Parietal to frontal direction of the information flux within EEG functional coupling was stronger in Nold than in MCI and/or AD subjects, namely for alpha and beta rhythms. In contrast, the directional flow within inter-hemispheric EEG functional coupling did not discriminate among the three groups. These results suggest that directionality of parieto-to-frontal EEG synchronization is abnormal not only in AD but also in amnesic MCI.",

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Directionality of EEG synchronization in Alzheimer's disease subjects

Abstract

Keywords

ASJC Scopus subject areas

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