TY - JOUR
T1 - Directionality of EEG synchronization in Alzheimer's disease subjects
AU - Babiloni, Claudio
AU - Ferri, Raffaele
AU - Binetti, Giuliano
AU - Vecchio, Fabrizio
AU - Frisoni, Giovanni B.
AU - Lanuzza, Bartolo
AU - Miniussi, Carlo
AU - Nobili, Flavio
AU - Rodriguez, Guido
AU - Rundo, Francesco
AU - Cassarino, Andrea
AU - Infarinato, Francesco
AU - Cassetta, Emanuele
AU - Salinari, Serenella
AU - Eusebi, Fabrizio
AU - Rossini, Paolo M.
PY - 2009/1
Y1 - 2009/1
N2 - Is directionality of electroencephalographic (EEG) synchronization abnormal in amnesic mild cognitive impairment (MCI) and Alzheimer's disease (AD)? EEG data were recorded in 64 normal elderly (Nold), 69 amnesic MCI, and 73 mild AD subjects at rest condition (closed eyes). Direction of information flux within EEG functional coupling at electrode pairs was performed by directed transfer function (DTF) at delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10 Hz), alpha 2 (10-12 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz). Parietal to frontal direction of the information flux within EEG functional coupling was stronger in Nold than in MCI and/or AD subjects, namely for alpha and beta rhythms. In contrast, the directional flow within inter-hemispheric EEG functional coupling did not discriminate among the three groups. These results suggest that directionality of parieto-to-frontal EEG synchronization is abnormal not only in AD but also in amnesic MCI.
AB - Is directionality of electroencephalographic (EEG) synchronization abnormal in amnesic mild cognitive impairment (MCI) and Alzheimer's disease (AD)? EEG data were recorded in 64 normal elderly (Nold), 69 amnesic MCI, and 73 mild AD subjects at rest condition (closed eyes). Direction of information flux within EEG functional coupling at electrode pairs was performed by directed transfer function (DTF) at delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10 Hz), alpha 2 (10-12 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz). Parietal to frontal direction of the information flux within EEG functional coupling was stronger in Nold than in MCI and/or AD subjects, namely for alpha and beta rhythms. In contrast, the directional flow within inter-hemispheric EEG functional coupling did not discriminate among the three groups. These results suggest that directionality of parieto-to-frontal EEG synchronization is abnormal not only in AD but also in amnesic MCI.
KW - Directed transfer function (DTF)
KW - Electroencephalography (EEG)
KW - Mild Alzheimer's disease (mild AD)
KW - Mild cognitive impairment (MCI)
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U2 - 10.1016/j.neurobiolaging.2007.05.007
DO - 10.1016/j.neurobiolaging.2007.05.007
M3 - Article
C2 - 17573161
AN - SCOPUS:56249129291
VL - 30
SP - 93
EP - 102
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 1
ER -