Disability, anxiety and depression associated with medication-overuse headache can be considerably reduced by detoxification and prophylactic treatment. Results from a multicentre, multinational study (COMOESTAS project)

L. Bendtsen, S. B. Munksgaard, C. Tassorelli, G. Nappi, Z. Katsarava, M. Lainez, J. A. Leston, R. Fadic, S. Spadafora, A. Stoppini, R. Jensen

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The objective of this article is to investigate whether headache-related disability, depression and anxiety can be reduced by detoxification and prophylactic treatment in patients with medication-overuse headache (MOH). Methods: Patients with MOH were included from six centres in Europe and Latin America in a seven-month cohort study. Before and six months after treatment, the degree of disability was measured by the Migraine Disability Assessment (MIDAS) questionnaire, while anxiety and depression were measured by the Hospital Anxiety and Depression Scale (HADS). Results: A total of 694 patients with MOH were included, of whom 492 completed the study. Headache days were reduced by 58.4% from 23.6 to 9.8 days per month at six months (p

Original languageEnglish
Pages (from-to)426-433
Number of pages8
JournalCephalalgia
Volume34
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • anxiety
  • depression
  • detoxification
  • disability
  • management
  • Medication-overuse headache

ASJC Scopus subject areas

  • Clinical Neurology
  • Medicine(all)

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