Disappearance of oxidative damage to red blood cell membranes in uremic patients following renal transplant

M. Taccone-Gallucci, R. Lubrano, A. Belli, C. Meloni, M. Moroset ti, L. Meschini, M. Elli, V. Boffo, F. Pisani, O. Giardini, C. U. Cas ciani

Research output: Contribution to journalArticle

Abstract

Hemodialysis patients display increased oxidative damage to red blood cell (RBC) membranes, characterized by elevated levels of malonyldialdehyde (MDA), a short chain aldehyde produced by the oxidation of the polyunsaturated fatty acids (PUFA) in the RBC membranes. This is the result of a metabolic blockage of the pentose-phosphate shunt in uremic patients, which causes reduced detoxification of highly oxidative free radicals. The oxidative damage induces increased RBC rigidity and decreased RBC deformability, therefore favoring hemolysis. The aim of this work was to determine if a functioning renal graft would restore normal erythrocyte metabolism, reducing the oxidative damage. To this end, we have determined RBC MDA concentrations in 20 hemodialysis (HD) patients (RBC MDA 18.22 ± 4.36 μg/ml packed RBC), 20 renal transplant (T) patients with well functioning grafts (serum creatinine <2 mg%) (RBC MDA 1.2 ± 0.4 μg/ml packed RBC) (T vs. HD p <0.005) and 20 healthy controls (HC) (RBC MDA 1.44 ± 0.6 μg/ml packed RBC) (HC vs. HD P <0.005; HC vs. T NS). Our findings show that a well-functioning renal graft restores normal RBC metabolism and eliminates the oxidative damage induced by uremia.

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalASAIO transactions / American Society for Artificial Internal Organs
Volume35
Issue number3
Publication statusPublished - Jul 1989

ASJC Scopus subject areas

  • Biophysics

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    Taccone-Gallucci, M., Lubrano, R., Belli, A., Meloni, C., Moroset ti, M., Meschini, L., Elli, M., Boffo, V., Pisani, F., Giardini, O., & Cas ciani, C. U. (1989). Disappearance of oxidative damage to red blood cell membranes in uremic patients following renal transplant. ASAIO transactions / American Society for Artificial Internal Organs, 35(3), 533-535.