Disappearance rate of serum calcitonin after total thyroidectomy for medullary thyroid carcinoma

L. Fugazzola, A. Pinchera, F. Luchetti, P. Iacconi, P. Miccoli, C. Romei, M. Puccini, F. Pacini

Research output: Contribution to journalArticle

Abstract

We studied the half-life of serum calcitonin (CT) in patients subjected to total thyroidectomy for medullary thyroid carcinoma (MTC). One patient showed a rapid serum CT component with a half-life of 3 hours and a slow component with a half-life of 30 hours, in another case only the 30-hour component was found. By chromatography of tumor extracts, we found that all the immunoreactive CT had a molecular weight of 3,600. After surgery, normalization of serum CT vas achieved within 15 days in 4 patients, at 3 months and at 6 months in 2 other patients, while 1 patient never normalized. Normalization of serum CT after surgery is not an index of definitive cure in MTC, as demonstrated by one patient who relapsed 3 months after normalization of serum CT. However, as a general rule, patients who reach undetectable serum CT levels soon after surgery, are those having the best prognosis.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalInternational Journal of Biological Markers
Volume9
Issue number1
Publication statusPublished - 1994

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Thyroidectomy
Calcitonin
Serum
Surgery
Half-Life
Chromatography
Medullary Thyroid cancer
Tumors
Molecular Weight
Molecular weight
Neoplasms

Keywords

  • calcitonin
  • half-life
  • medullary thyroid cancer
  • tumor markers

ASJC Scopus subject areas

  • Biochemistry
  • Immunology

Cite this

Fugazzola, L., Pinchera, A., Luchetti, F., Iacconi, P., Miccoli, P., Romei, C., ... Pacini, F. (1994). Disappearance rate of serum calcitonin after total thyroidectomy for medullary thyroid carcinoma. International Journal of Biological Markers, 9(1), 21-24.

Disappearance rate of serum calcitonin after total thyroidectomy for medullary thyroid carcinoma. / Fugazzola, L.; Pinchera, A.; Luchetti, F.; Iacconi, P.; Miccoli, P.; Romei, C.; Puccini, M.; Pacini, F.

In: International Journal of Biological Markers, Vol. 9, No. 1, 1994, p. 21-24.

Research output: Contribution to journalArticle

Fugazzola, L, Pinchera, A, Luchetti, F, Iacconi, P, Miccoli, P, Romei, C, Puccini, M & Pacini, F 1994, 'Disappearance rate of serum calcitonin after total thyroidectomy for medullary thyroid carcinoma', International Journal of Biological Markers, vol. 9, no. 1, pp. 21-24.
Fugazzola L, Pinchera A, Luchetti F, Iacconi P, Miccoli P, Romei C et al. Disappearance rate of serum calcitonin after total thyroidectomy for medullary thyroid carcinoma. International Journal of Biological Markers. 1994;9(1):21-24.
Fugazzola, L. ; Pinchera, A. ; Luchetti, F. ; Iacconi, P. ; Miccoli, P. ; Romei, C. ; Puccini, M. ; Pacini, F. / Disappearance rate of serum calcitonin after total thyroidectomy for medullary thyroid carcinoma. In: International Journal of Biological Markers. 1994 ; Vol. 9, No. 1. pp. 21-24.
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