Disappearance rate of serum calcitonin after total thyroidectomy for medullary thyroid carcinoma

L. Fugazzola, A. Pinchera, F. Luchetti, P. Iacconi, P. Miccoli, C. Romei, M. Puccini, F. Pacini

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the half-life of serum calcitonin (CT) in patients subjected to total thyroidectomy for medullary thyroid carcinoma (MTC). One patient showed a rapid serum CT component with a half-life of 3 hours and a slow component with a half-life of 30 hours, in another case only the 30-hour component was found. By chromatography of tumor extracts, we found that all the immunoreactive CT had a molecular weight of 3,600. After surgery, normalization of serum CT vas achieved within 15 days in 4 patients, at 3 months and at 6 months in 2 other patients, while 1 patient never normalized. Normalization of serum CT after surgery is not an index of definitive cure in MTC, as demonstrated by one patient who relapsed 3 months after normalization of serum CT. However, as a general rule, patients who reach undetectable serum CT levels soon after surgery, are those having the best prognosis.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalInternational Journal of Biological Markers
Volume9
Issue number1
Publication statusPublished - 1994

Keywords

  • calcitonin
  • half-life
  • medullary thyroid cancer
  • tumor markers

ASJC Scopus subject areas

  • Biochemistry
  • Immunology

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