Disarming dendritic cells: A tumor strategy to escape from immune control

Silvia Della Bella, Mario Clerici, Maria Luisa Villa

Research output: Contribution to journalArticle

Abstract

Although the immune system is clearly capable of recognizing and eliminating tumor cells, it usually fails to provide adequate protective antitumor responses. it is becoming increasingly clear that modifications of dendritic cells (DCs), which are central regulators of immune responses, could be a strategy exploited by tumor cells to escape from immune control. This review focuses on the current understanding of DC defects occurring in cancer patients, mechanisms responsible for the induction of such defects, consequences of DC defects on antitumor immune response and current concepts of DC-based immunotherapy. An improved understanding of how tumors interact with DCs to escape from immune control may enable the design of improved DC-based immunotherapeutic strategies for patients with cancer.

Original languageEnglish
Pages (from-to)411-422
Number of pages12
JournalExpert Review of Clinical Immunology
Volume3
Issue number3
DOIs
Publication statusPublished - May 2007

Keywords

  • Antitumor immunity
  • Cancer immunotherapy
  • Cellular vaccine
  • Dendritic cell
  • Immune escape
  • Immune modifier
  • Tumor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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