Discharge patterns in the subthalamic nucleus and substantia nigra during deep brain stimulator implants

M. Rohr, G. Baselli, A. M. Bianchi, S. Cerutti, F. Tamma, E. Caputo, M. Egidi, P. Rampini, M. Locatelli, A. Pesenti, A. Priori

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

8 patients affected by Parkinson's disease underwent implantation of stimulating electrodes in both subthalamic nuclei (STN). The stereotactic track was explored by a 1 MΩ microelectrode and recordings were taken at different depths, from 5 mm before down to 5 mm beyond the target, with a 1 mm step. At rest, in 8 out of the 16 successful tracks, spikes were recognizable in correspondence to the STN and in 2 in correspondence to the substantia nigra (SN) beyond the target. Spikes were detected by a matched filtering and threshold algorithm. The spike shape was analyzed by the rise time (0.199±0.064 msec, mean±SD, in the STN), decay time (0.345±0.114 msec) and bandwidth (1.612±0.622 kHz, -3dB). The discharge patterns were analyzed through the inter spike interval (ISI) histogram, the conditional intensity function (CIF) and the spectrum of counts. The mean interval was 33.3±11.9 msec. Apart a single case of rhythmicity (1.65 Hz), the discharge pattern in the STN was always Poisson like with or without the presence of short bursts, as reveled by a flat CIF. Rhythmic patterns were found in SN.

Original languageEnglish
Title of host publicationAnnual Reports of the Research Reactor Institute, Kyoto University
Pages972-974
Number of pages3
Volume1
Publication statusPublished - 2001
Event23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Istanbul, Turkey
Duration: Oct 25 2001Oct 28 2001

Other

Other23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CountryTurkey
CityIstanbul
Period10/25/0110/28/01

Keywords

  • Deep brain stimulation
  • Event series analysis
  • Microneurographic recordings
  • Parkinson's disease

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Mechanical Engineering

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