Discoidin domain receptor-1 and periostin: New players in chronic kidney disease

Carlo Alfieri, Panagiotis Kavvadas, Paola Simonini, Masami Ikehata, Jean Claude Dussaule, Christos E. Chadjichristos, Maria Pia Rastaldi, Piergiorgio Messa, Christos Chatziantoniou

Research output: Contribution to journalArticlepeer-review

Abstract

The incidence and prevalence of chronic kidney disease represents an important problem for public health. In renal diseases, the main histologic alterations derive from the development of renal fibrosis which results from the loss of the balance between proand anti-fibrotic factors. Tyrosine kinase receptors (RTKs) and matricellular proteins (MPs) are nowadays studied as potential modulators of renal injury. RTKs regulate cell cycle, migration, metabolism and cellular differentiation. Discoidin domain receptor-1 (DDR-1) is an RTK that has been extensively studied in cancer, and lung and renal diseases. It modulates inflammatory recruitment, extracellular matrix deposition and fibrosis; in renal diseases, it appears to act independently of the underlying disease. MPs regulate cell-matrix interactions and matrix accumulation, cellular adhesion and migration, and expression of inflammatory cells. Periostin is an MP, mainly studied in bone, heart, lung and cancer. Several studies demonstrated that it mediates cellmatrix interactions, migration of inflammatory cells and development of fibrosis. Recently, it has been reported in several nephropathies. In this review, we discuss the potential pathological roles of DDR-1 and periostin focussing on the kidney in both experimental models and human diseases.

Original languageEnglish
Pages (from-to)1965-1971
Number of pages7
JournalNephrology Dialysis Transplantation
Volume30
Issue number12
DOIs
Publication statusPublished - 2015

Keywords

  • Discoidin Domain Receptor-1
  • Matricellular Proteins
  • Periostin
  • Renal Fibrosis
  • Tyrosine Kinase Receptors

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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