Disconnection between periodic leg movements and cortical arousals in spinal cord injury

Aaro V. Salminen, Mauro Manconi, Ville Rimpilä, Teemu M. Luoto, Eerika Koskinen, Raffaele Ferri, Juha Öhman, Olli Polo

Research output: Contribution to journalArticle

Abstract

Objective: In this study we examine the temporal connection between periodic leg movements (PLMs) and cortical arousals, as well as the treatment effect of pramipexole, in a clinical case with spinal cord lesion. Methods: A patient with complete cervical spinal cord injury and PLMs during sleep underwent two baseline sleep recordings, one recording with dopaminergic treatment, and one recording with adaptive servoventilation. Results: The PLMs were temporally dissociated from cortical arousals as well as from respiratory or heart rate events. PLMs were suppressed by pramipexole and persisted after treatment of apnea. Conclusion: The disconnection of PLMs from arousals supports a spinal generator or peripheral trigger mechanism for PLMs. The suppression of movements by a dopamine agonist suggests that its site of action is caudal to the cervical lesion and outside of the brain. Our observation provides significant new knowledge about the pathogenesis of PLMs and warrants studies in larger populations.

Original languageEnglish
Pages (from-to)1207-1209
Number of pages3
JournalJournal of Clinical Sleep Medicine
Volume9
Issue number11
DOIs
Publication statusPublished - 2013

Fingerprint

Arousal
Spinal Cord Injuries
Leg
Sleep
Dopamine Agonists
Apnea
Respiratory Rate
Spinal Cord
Therapeutics
Heart Rate
Observation
Brain
Population

Keywords

  • Case report
  • Cortical arousal
  • Dopamine agonist
  • Periodic leg movements
  • Sleep apnea
  • Spinal cord injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Pulmonary and Respiratory Medicine
  • Neurology

Cite this

Salminen, A. V., Manconi, M., Rimpilä, V., Luoto, T. M., Koskinen, E., Ferri, R., ... Polo, O. (2013). Disconnection between periodic leg movements and cortical arousals in spinal cord injury. Journal of Clinical Sleep Medicine, 9(11), 1207-1209. https://doi.org/10.5664/jcsm.3174

Disconnection between periodic leg movements and cortical arousals in spinal cord injury. / Salminen, Aaro V.; Manconi, Mauro; Rimpilä, Ville; Luoto, Teemu M.; Koskinen, Eerika; Ferri, Raffaele; Öhman, Juha; Polo, Olli.

In: Journal of Clinical Sleep Medicine, Vol. 9, No. 11, 2013, p. 1207-1209.

Research output: Contribution to journalArticle

Salminen, AV, Manconi, M, Rimpilä, V, Luoto, TM, Koskinen, E, Ferri, R, Öhman, J & Polo, O 2013, 'Disconnection between periodic leg movements and cortical arousals in spinal cord injury', Journal of Clinical Sleep Medicine, vol. 9, no. 11, pp. 1207-1209. https://doi.org/10.5664/jcsm.3174
Salminen, Aaro V. ; Manconi, Mauro ; Rimpilä, Ville ; Luoto, Teemu M. ; Koskinen, Eerika ; Ferri, Raffaele ; Öhman, Juha ; Polo, Olli. / Disconnection between periodic leg movements and cortical arousals in spinal cord injury. In: Journal of Clinical Sleep Medicine. 2013 ; Vol. 9, No. 11. pp. 1207-1209.
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