Discontinuation of phenobarbital in children: Effects on neurocognitive behavior

Daria Riva, Monica Devoti

Research output: Contribution to journalArticlepeer-review


Neurocognitive performances were evaluated in 9 children with different types of epilepsy prior to and at least 6 months after discontinuation of phenobarbital. The patients treated with phenobarbital monotherapy were seizure free for at least 2 years, without electroencephalographic anomalies for at least 1 year. Results indicated that phenobarbital at low therapeutic doses causes attentional and memory deficits, reversible after therapy discontinuation. Further research utilizing the same design is needed on larger samples in order to confirm our results.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalPediatric Neurology
Issue number1
Publication statusPublished - Jan 1996

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology


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