Abstract
During regeneration of rat livers following 70% hepatectomy, insulin binding sites on hepatocyte plasma membranes are increased after 24-48 hours, glucagon binding sites are reduced on days 2-8, and the resultant insulin/glucagon binding ratio is markedly increased. An apparent paradox was the finding of a depression of the activity of an insulin associated enzyme, glucokinase, at a time when the number of insulin binding sites was increased.
| Original language | English |
|---|---|
| Pages (from-to) | 47-50 |
| Number of pages | 4 |
| Journal | Hormone and Metabolic Research |
| Volume | 16 |
| Issue number | SUPPL. 1 |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology
Cite this
Discordance between glucokinase activity and insulin and glucagon receptor changes occurring during liver regeneration in the rat. / Francavilla, A.; Di Leo, A.; Wu, S. Q.; Ove, P.; Van Thiel, D.; Sciascia, C.; Starzl, T. E.
In: Hormone and Metabolic Research, Vol. 16, No. SUPPL. 1, 1984, p. 47-50.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Discordance between glucokinase activity and insulin and glucagon receptor changes occurring during liver regeneration in the rat
AU - Francavilla, A.
AU - Di Leo, A.
AU - Wu, S. Q.
AU - Ove, P.
AU - Van Thiel, D.
AU - Sciascia, C.
AU - Starzl, T. E.
PY - 1984
Y1 - 1984
N2 - During regeneration of rat livers following 70% hepatectomy, insulin binding sites on hepatocyte plasma membranes are increased after 24-48 hours, glucagon binding sites are reduced on days 2-8, and the resultant insulin/glucagon binding ratio is markedly increased. An apparent paradox was the finding of a depression of the activity of an insulin associated enzyme, glucokinase, at a time when the number of insulin binding sites was increased.
AB - During regeneration of rat livers following 70% hepatectomy, insulin binding sites on hepatocyte plasma membranes are increased after 24-48 hours, glucagon binding sites are reduced on days 2-8, and the resultant insulin/glucagon binding ratio is markedly increased. An apparent paradox was the finding of a depression of the activity of an insulin associated enzyme, glucokinase, at a time when the number of insulin binding sites was increased.
UR - http://www.scopus.com/inward/record.url?scp=0021703984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021703984&partnerID=8YFLogxK
M3 - Article
VL - 16
SP - 47
EP - 50
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
SN - 0018-5043
IS - SUPPL. 1
ER -