Discordance between glucokinase activity and insulin and glucagon receptor changes occurring during liver regeneration in the rat

A. Francavilla, A. Di Leo, S. Q. Wu, P. Ove, D. Van Thiel, C. Sciascia, T. E. Starzl

Research output: Contribution to journalArticle

Abstract

During regeneration of rat livers following 70% hepatectomy, insulin binding sites on hepatocyte plasma membranes are increased after 24-48 hours, glucagon binding sites are reduced on days 2-8, and the resultant insulin/glucagon binding ratio is markedly increased. An apparent paradox was the finding of a depression of the activity of an insulin associated enzyme, glucokinase, at a time when the number of insulin binding sites was increased.

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalHormone and Metabolic Research
Volume16
Issue numberSUPPL. 1
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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    Francavilla, A., Di Leo, A., Wu, S. Q., Ove, P., Van Thiel, D., Sciascia, C., & Starzl, T. E. (1984). Discordance between glucokinase activity and insulin and glucagon receptor changes occurring during liver regeneration in the rat. Hormone and Metabolic Research, 16(SUPPL. 1), 47-50.