Discordance rate between radiolabelled choline PET/CT and bone scintigraphy in detecting bone metastases in patients with prostate cancer: A meta-analysis

Giorgio Treglia, Carlo Vigneri, Ramin Sadeghi, Laura Evangelista, Luca Ceriani, Luca Giovanella

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The objective of the study was to systematically review published data and perform a meta-analysis about the discordance rate between radiolabelled choline PET/CT and bone scintigraphy (BS) in detecting bone metastases in patients with prostate cancer (PCa). A comprehensive literature search of studies or subsets of studies published through November 2014 including information on the comparison among radiolabelled choline PET/CT and bone scintigraphy in PCa patients was carried out. A meta-analysis was performed in order to calculate the pooled discordance rate among these methods in detecting bone metastases on a per patient-based analysis. Twelve articles were selected. The pooled discordance rate among radiolabelled choline PET/CT and BS in detecting bone metastases was 10.9 % (95 % confidence interval 6.3–16.7 %). Discordant findings were due to radiolabelled choline positive and BS negative or inconclusive findings, but BS positive and radiolabelled choline-negative findings also occurred. We discuss the possible causes of discordant findings. Discordance rate between radiolabelled choline PET/CT and BS in detecting bone metastases in PCa patients is not negligible and both methods are useful in this setting.

Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalClinical and Translational Imaging
Volume3
Issue number2
DOIs
Publication statusPublished - Apr 1 2015

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Choline
Radionuclide Imaging
Meta-Analysis
Prostatic Neoplasms
Neoplasm Metastasis
Bone and Bones
Confidence Intervals

Keywords

  • Bone metastasis
  • Bone scintigraphy
  • Choline
  • Positron emission tomography
  • Prostate cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Discordance rate between radiolabelled choline PET/CT and bone scintigraphy in detecting bone metastases in patients with prostate cancer : A meta-analysis. / Treglia, Giorgio; Vigneri, Carlo; Sadeghi, Ramin; Evangelista, Laura; Ceriani, Luca; Giovanella, Luca.

In: Clinical and Translational Imaging, Vol. 3, No. 2, 01.04.2015, p. 133-140.

Research output: Contribution to journalReview article

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