Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study

Scott L. Weiss; Julie C. Fitzgerald; Frank A. Maffei; Jason M. Kane; Antonio Rodriguez-Nunez; Deyin D. Hsing; Deborah Franzon; Sze Ying Kee; Jenny L. Bush; Jason A. Roy; Neal J. Thomas; Vinay M. Nadkarni; P. Fontela; M. Tucci; M. Dumistrascu; P. Skippen; G. Krahn; E. Bezares; G. Puig; A. Puig-Ramos; R. Garcia; M. Villar; M. Bigham; T. Polanski; S. Latifi; D. Giebner; H. Anthony; J. Hume; A. Galster; L. Linnerud; R. Sanders; G. Hefley; K. Madden; A. Thompson; S. Shein; S. Gertz; Y. Han; T. Williams; A. Hughes-Schalk; H. Chandler; A. Orioles; E. Zielinski; A. Doucette; A. Orioles; E. Zielinski; A. Doucette; M. Di Nardo; S. Picardo; T. Fragasso; P. Cogo; for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

doi:10.1186/s13054-015-1055-x

Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study

Scott L. Weiss, Julie C. Fitzgerald, Frank A. Maffei, Jason M. Kane, Antonio Rodriguez-Nunez, Deyin D. Hsing, Deborah Franzon, Sze Ying Kee, Jenny L. Bush, Jason A. Roy, Neal J. Thomas, Vinay M. Nadkarni, P. Fontela, M. Tucci, M. Dumistrascu, P. Skippen, G. Krahn, E. Bezares, G. Puig, A. Puig-RamosR. Garcia, M. Villar, M. Bigham, T. Polanski, S. Latifi, D. Giebner, H. Anthony, J. Hume, A. Galster, L. Linnerud, R. Sanders, G. Hefley, K. Madden, A. Thompson, S. Shein, S. Gertz, Y. Han, T. Williams, A. Hughes-Schalk, H. Chandler, A. Orioles, E. Zielinski, A. Doucette, A. Orioles, E. Zielinski, A. Doucette, M. Di Nardo, S. Picardo, T. Fragasso, P. Cogo, for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Ospedale Pediatrico Bambino Gesu

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Abstract

Introduction: Consensus criteria for pediatric severe sepsis have standardized enrollment for research studies. However, the extent to which critically ill children identified by consensus criteria reflect physician diagnosis of severe sepsis, which underlies external validity for pediatric sepsis research, is not known. We sought to determine the agreement between physician diagnosis and consensus criteria to identify pediatric patients with severe sepsis across a network of international pediatric intensive care units (PICUs). Methods: We conducted a point prevalence study involving 128 PICUs in 26 countries across 6 continents. Over the course of 5 study days, 6925 PICU patients

Original language	English
Article number	325
Journal	Critical Care
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s13054-015-1055-x
Publication status	Published - Sep 16 2015

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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10.1186/s13054-015-1055-x

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Weiss, S. L., Fitzgerald, J. C., Maffei, F. A., Kane, J. M., Rodriguez-Nunez, A., Hsing, D. D., Franzon, D., Kee, S. Y., Bush, J. L., Roy, J. A., Thomas, N. J., Nadkarni, V. M., Fontela, P., Tucci, M., Dumistrascu, M., Skippen, P., Krahn, G., Bezares, E., Puig, G., ... for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network (2015). Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study. Critical Care, 19(1), [325]. https://doi.org/10.1186/s13054-015-1055-x

Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study. / Weiss, Scott L.; Fitzgerald, Julie C.; Maffei, Frank A.; Kane, Jason M.; Rodriguez-Nunez, Antonio; Hsing, Deyin D.; Franzon, Deborah; Kee, Sze Ying; Bush, Jenny L.; Roy, Jason A.; Thomas, Neal J.; Nadkarni, Vinay M.; Fontela, P.; Tucci, M.; Dumistrascu, M.; Skippen, P.; Krahn, G.; Bezares, E.; Puig, G.; Puig-Ramos, A.; Garcia, R.; Villar, M.; Bigham, M.; Polanski, T.; Latifi, S.; Giebner, D.; Anthony, H.; Hume, J.; Galster, A.; Linnerud, L.; Sanders, R.; Hefley, G.; Madden, K.; Thompson, A.; Shein, S.; Gertz, S.; Han, Y.; Williams, T.; Hughes-Schalk, A.; Chandler, H.; Orioles, A.; Zielinski, E.; Doucette, A.; Orioles, A.; Zielinski, E.; Doucette, A.; Di Nardo, M.; Picardo, S.; Fragasso, T.; Cogo, P.; for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

In: Critical Care, Vol. 19, No. 1, 325, 16.09.2015.

Research output: Contribution to journal › Article › peer-review

Weiss, SL, Fitzgerald, JC, Maffei, FA, Kane, JM, Rodriguez-Nunez, A, Hsing, DD, Franzon, D, Kee, SY, Bush, JL, Roy, JA, Thomas, NJ, Nadkarni, VM, Fontela, P, Tucci, M, Dumistrascu, M, Skippen, P, Krahn, G, Bezares, E, Puig, G, Puig-Ramos, A, Garcia, R, Villar, M, Bigham, M, Polanski, T, Latifi, S, Giebner, D, Anthony, H, Hume, J, Galster, A, Linnerud, L, Sanders, R, Hefley, G, Madden, K, Thompson, A, Shein, S, Gertz, S, Han, Y, Williams, T, Hughes-Schalk, A, Chandler, H, Orioles, A, Zielinski, E, Doucette, A, Orioles, A, Zielinski, E, Doucette, A, Di Nardo, M , Picardo, S , Fragasso, T, Cogo, P & for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network 2015, 'Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study', Critical Care, vol. 19, no. 1, 325. https://doi.org/10.1186/s13054-015-1055-x

Weiss, Scott L. ; Fitzgerald, Julie C. ; Maffei, Frank A. ; Kane, Jason M. ; Rodriguez-Nunez, Antonio ; Hsing, Deyin D. ; Franzon, Deborah ; Kee, Sze Ying ; Bush, Jenny L. ; Roy, Jason A. ; Thomas, Neal J. ; Nadkarni, Vinay M. ; Fontela, P. ; Tucci, M. ; Dumistrascu, M. ; Skippen, P. ; Krahn, G. ; Bezares, E. ; Puig, G. ; Puig-Ramos, A. ; Garcia, R. ; Villar, M. ; Bigham, M. ; Polanski, T. ; Latifi, S. ; Giebner, D. ; Anthony, H. ; Hume, J. ; Galster, A. ; Linnerud, L. ; Sanders, R. ; Hefley, G. ; Madden, K. ; Thompson, A. ; Shein, S. ; Gertz, S. ; Han, Y. ; Williams, T. ; Hughes-Schalk, A. ; Chandler, H. ; Orioles, A. ; Zielinski, E. ; Doucette, A. ; Orioles, A. ; Zielinski, E. ; Doucette, A. ; Di Nardo, M. ; Picardo, S. ; Fragasso, T. ; Cogo, P. ; for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. / Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study. In: Critical Care. 2015 ; Vol. 19, No. 1.

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title = "Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study",

abstract = "Introduction: Consensus criteria for pediatric severe sepsis have standardized enrollment for research studies. However, the extent to which critically ill children identified by consensus criteria reflect physician diagnosis of severe sepsis, which underlies external validity for pediatric sepsis research, is not known. We sought to determine the agreement between physician diagnosis and consensus criteria to identify pediatric patients with severe sepsis across a network of international pediatric intensive care units (PICUs). Methods: We conducted a point prevalence study involving 128 PICUs in 26 countries across 6 continents. Over the course of 5 study days, 6925 PICU patients ",

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AU - Weiss, Scott L.

AU - Fitzgerald, Julie C.

AU - Maffei, Frank A.

AU - Kane, Jason M.

AU - Rodriguez-Nunez, Antonio

AU - Hsing, Deyin D.

AU - Franzon, Deborah

AU - Kee, Sze Ying

AU - Bush, Jenny L.

AU - Roy, Jason A.

AU - Thomas, Neal J.

AU - Nadkarni, Vinay M.

AU - Fontela, P.

AU - Tucci, M.

AU - Dumistrascu, M.

AU - Skippen, P.

AU - Krahn, G.

AU - Bezares, E.

AU - Puig, G.

AU - Puig-Ramos, A.

AU - Garcia, R.

AU - Villar, M.

AU - Bigham, M.

AU - Polanski, T.

AU - Latifi, S.

AU - Giebner, D.

AU - Anthony, H.

AU - Hume, J.

AU - Galster, A.

AU - Linnerud, L.

AU - Sanders, R.

AU - Hefley, G.

AU - Madden, K.

AU - Thompson, A.

AU - Shein, S.

AU - Gertz, S.

AU - Han, Y.

AU - Williams, T.

AU - Hughes-Schalk, A.

AU - Chandler, H.

AU - Orioles, A.

AU - Zielinski, E.

AU - Doucette, A.

AU - Orioles, A.

AU - Zielinski, E.

AU - Doucette, A.

AU - Di Nardo, M.

AU - Picardo, S.

AU - Fragasso, T.

AU - Cogo, P.

AU - for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

PY - 2015/9/16

Y1 - 2015/9/16

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ER -

Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study

Abstract

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