Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study

Scott L. Weiss, Julie C. Fitzgerald, Frank A. Maffei, Jason M. Kane, Antonio Rodriguez-Nunez, Deyin D. Hsing, Deborah Franzon, Sze Ying Kee, Jenny L. Bush, Jason A. Roy, Neal J. Thomas, Vinay M. Nadkarni, P. Fontela, M. Tucci, M. Dumistrascu, P. Skippen, G. Krahn, E. Bezares, G. Puig, A. Puig-RamosR. Garcia, M. Villar, M. Bigham, T. Polanski, S. Latifi, D. Giebner, H. Anthony, J. Hume, A. Galster, L. Linnerud, R. Sanders, G. Hefley, K. Madden, A. Thompson, S. Shein, S. Gertz, Y. Han, T. Williams, A. Hughes-Schalk, H. Chandler, A. Orioles, E. Zielinski, A. Doucette, A. Orioles, E. Zielinski, A. Doucette, M. Di Nardo, S. Picardo, T. Fragasso, P. Cogo, for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

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Abstract

Introduction: Consensus criteria for pediatric severe sepsis have standardized enrollment for research studies. However, the extent to which critically ill children identified by consensus criteria reflect physician diagnosis of severe sepsis, which underlies external validity for pediatric sepsis research, is not known. We sought to determine the agreement between physician diagnosis and consensus criteria to identify pediatric patients with severe sepsis across a network of international pediatric intensive care units (PICUs). Methods: We conducted a point prevalence study involving 128 PICUs in 26 countries across 6 continents. Over the course of 5 study days, 6925 PICU patients

Original languageEnglish
Article number325
JournalCritical Care
Volume19
Issue number1
DOIs
Publication statusPublished - Sep 16 2015

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ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Weiss, S. L., Fitzgerald, J. C., Maffei, F. A., Kane, J. M., Rodriguez-Nunez, A., Hsing, D. D., Franzon, D., Kee, S. Y., Bush, J. L., Roy, J. A., Thomas, N. J., Nadkarni, V. M., Fontela, P., Tucci, M., Dumistrascu, M., Skippen, P., Krahn, G., Bezares, E., Puig, G., ... for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network (2015). Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study. Critical Care, 19(1), [325]. https://doi.org/10.1186/s13054-015-1055-x