Discovering Che-1/AATF: A new attractive target for cancer therapy

Simona Iezzi, Maurizio Fanciulli

Research output: Contribution to journalArticle

Abstract

The transcriptional cofactor Che-1/AATF is currently emerging as an important component of the DNA damage response machinery, the complex signaling network that maintains genome integrity and prevents tumorigenesis. Moreover this protein is involved in a wide range of cellular pathways, regulating proliferation and survival in both physiological and pathological conditions. Notably, some evidence indicates that dysregulation of Che-1/AATF levels are associated with the transformation process and elevated levels of Che-1/AATF are required for tumor cell survival. It is for these reasons that Che-1/AATF has been regarded as an attractive, still theoretical, therapeutic target for cancer treatments. In this review, we will provide an updated overview of Che-1/AATF activities, from transcriptional regulation to DNA damage response.

Original languageEnglish
Article number141
JournalFrontiers in Genetics
Volume6
Issue numberMAR
DOIs
Publication statusPublished - 2015

Keywords

  • Apoptosis
  • Cell cycle regulation
  • Cellular stress
  • Che-1/AATF
  • DNA damage response
  • Survival
  • Transcription

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Genetics(clinical)

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