Discovertebral erosions in patients with enteropathic spondyloarthritis

Rosario Peluso, Matteo Nicola Dario Di Minno, Vincenzo Bruner, Ernesto Soscia, Fabiana Castiglione, Francesco Manguso, Salvatore Iervolino, Raffaele Scarpa

Research output: Contribution to journalArticle

Abstract

Objective. Magnetic resonance imaging (MRI) is considered the modality of choice for the diagnosis of spondyloarthropathy (SpA)-related spondylodiscitis, or discovertebral erosions (DE). Our aim was to analyze the prevalence and the clinical features of DE in patients with enteropathic SpA (EA) using MRI. Methods. We evaluated 72 patients with EA and 43 controls for the study. All patients and controls underwent rheumatological and gastroenterological clinical examinations, and demographic features were recorded. For each patient, these factors were also recorded: duration of inflammatory bowel disease and arthritis from onset to enrollment, history of viral and bacterial infections, and occurrence of previous major trauma to the spine. These scores were taken: Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Harvey-Bradshaw Index, and the Simple Clinical Colitis Activity Index. All subjects had MRI of the spine. Results. On the basis of inclusion criteria, 43 patients with EA were included in the study. Twenty-three had axial EA (axEA) and 20 had axial and peripheral subset EA (overlap subset or peripheral type 3; axphEA). Twenty-two patients with EA (15/7 axEA/axphEA) showed DE (30.55%; p <0.001). DE was significantly more prevalent in axEA subjects than in the overlap subset (p <0.001). In axEA, DE had a significant direct correlation with arthritis duration (r = 0.546, p = 0.007). Patients with DE showed BASDAI, BASMI, and BASFI scores significantly higher than patients without DE (p <0.001). Conclusion. We found a high prevalence of DE among patients with EA (30.55%), confirming that DE is an important characteristic aspect of SpA. We found a high prevalence in patients in the axphEA subset (31.82%), suggesting that DE could be a characterizing feature of the overlap subset. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)2332-2340
Number of pages9
JournalJournal of Rheumatology
Volume39
Issue number12
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Ankylosing Spondylitis
Baths
Spondylarthropathies
Magnetic Resonance Imaging
Arthritis
Spine
Discitis
Rheumatology
Virus Diseases
Colitis
Inflammatory Bowel Diseases
Bacterial Infections
Demography
Wounds and Injuries

Keywords

  • Discovertebral erosions
  • Enteropathic spondyloarthritis
  • Inflammatory bowel disease
  • Magnetic resonance imaging
  • Spondyloarthropathies

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Peluso, R., Di Minno, M. N. D., Bruner, V., Soscia, E., Castiglione, F., Manguso, F., ... Scarpa, R. (2012). Discovertebral erosions in patients with enteropathic spondyloarthritis. Journal of Rheumatology, 39(12), 2332-2340. https://doi.org/10.3899/jrheum.120415

Discovertebral erosions in patients with enteropathic spondyloarthritis. / Peluso, Rosario; Di Minno, Matteo Nicola Dario; Bruner, Vincenzo; Soscia, Ernesto; Castiglione, Fabiana; Manguso, Francesco; Iervolino, Salvatore; Scarpa, Raffaele.

In: Journal of Rheumatology, Vol. 39, No. 12, 12.2012, p. 2332-2340.

Research output: Contribution to journalArticle

Peluso, R, Di Minno, MND, Bruner, V, Soscia, E, Castiglione, F, Manguso, F, Iervolino, S & Scarpa, R 2012, 'Discovertebral erosions in patients with enteropathic spondyloarthritis', Journal of Rheumatology, vol. 39, no. 12, pp. 2332-2340. https://doi.org/10.3899/jrheum.120415
Peluso R, Di Minno MND, Bruner V, Soscia E, Castiglione F, Manguso F et al. Discovertebral erosions in patients with enteropathic spondyloarthritis. Journal of Rheumatology. 2012 Dec;39(12):2332-2340. https://doi.org/10.3899/jrheum.120415
Peluso, Rosario ; Di Minno, Matteo Nicola Dario ; Bruner, Vincenzo ; Soscia, Ernesto ; Castiglione, Fabiana ; Manguso, Francesco ; Iervolino, Salvatore ; Scarpa, Raffaele. / Discovertebral erosions in patients with enteropathic spondyloarthritis. In: Journal of Rheumatology. 2012 ; Vol. 39, No. 12. pp. 2332-2340.
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abstract = "Objective. Magnetic resonance imaging (MRI) is considered the modality of choice for the diagnosis of spondyloarthropathy (SpA)-related spondylodiscitis, or discovertebral erosions (DE). Our aim was to analyze the prevalence and the clinical features of DE in patients with enteropathic SpA (EA) using MRI. Methods. We evaluated 72 patients with EA and 43 controls for the study. All patients and controls underwent rheumatological and gastroenterological clinical examinations, and demographic features were recorded. For each patient, these factors were also recorded: duration of inflammatory bowel disease and arthritis from onset to enrollment, history of viral and bacterial infections, and occurrence of previous major trauma to the spine. These scores were taken: Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Harvey-Bradshaw Index, and the Simple Clinical Colitis Activity Index. All subjects had MRI of the spine. Results. On the basis of inclusion criteria, 43 patients with EA were included in the study. Twenty-three had axial EA (axEA) and 20 had axial and peripheral subset EA (overlap subset or peripheral type 3; axphEA). Twenty-two patients with EA (15/7 axEA/axphEA) showed DE (30.55{\%}; p <0.001). DE was significantly more prevalent in axEA subjects than in the overlap subset (p <0.001). In axEA, DE had a significant direct correlation with arthritis duration (r = 0.546, p = 0.007). Patients with DE showed BASDAI, BASMI, and BASFI scores significantly higher than patients without DE (p <0.001). Conclusion. We found a high prevalence of DE among patients with EA (30.55{\%}), confirming that DE is an important characteristic aspect of SpA. We found a high prevalence in patients in the axphEA subset (31.82{\%}), suggesting that DE could be a characterizing feature of the overlap subset. The Journal of Rheumatology",
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N2 - Objective. Magnetic resonance imaging (MRI) is considered the modality of choice for the diagnosis of spondyloarthropathy (SpA)-related spondylodiscitis, or discovertebral erosions (DE). Our aim was to analyze the prevalence and the clinical features of DE in patients with enteropathic SpA (EA) using MRI. Methods. We evaluated 72 patients with EA and 43 controls for the study. All patients and controls underwent rheumatological and gastroenterological clinical examinations, and demographic features were recorded. For each patient, these factors were also recorded: duration of inflammatory bowel disease and arthritis from onset to enrollment, history of viral and bacterial infections, and occurrence of previous major trauma to the spine. These scores were taken: Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Harvey-Bradshaw Index, and the Simple Clinical Colitis Activity Index. All subjects had MRI of the spine. Results. On the basis of inclusion criteria, 43 patients with EA were included in the study. Twenty-three had axial EA (axEA) and 20 had axial and peripheral subset EA (overlap subset or peripheral type 3; axphEA). Twenty-two patients with EA (15/7 axEA/axphEA) showed DE (30.55%; p <0.001). DE was significantly more prevalent in axEA subjects than in the overlap subset (p <0.001). In axEA, DE had a significant direct correlation with arthritis duration (r = 0.546, p = 0.007). Patients with DE showed BASDAI, BASMI, and BASFI scores significantly higher than patients without DE (p <0.001). Conclusion. We found a high prevalence of DE among patients with EA (30.55%), confirming that DE is an important characteristic aspect of SpA. We found a high prevalence in patients in the axphEA subset (31.82%), suggesting that DE could be a characterizing feature of the overlap subset. The Journal of Rheumatology

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