Disease burden and treatment history among adults with atopic dermatitis receiving systemic therapy: baseline characteristics of participants on the EUROSTAD prospective observational study

Marjolein de Bruin-Weller, Andrew E. Pink, Annalisa Patrizi, Ana M. Gimenez-Arnau, Tove Agner, Pierre Paul Roquet-Gravy, Silvia M. Ferrucci, Petr Arenberger, Ake Svensson, Marie L.A. Schuttelaar, Audrey Nosbaum, Shyamalie Jayawardena, Elena Rizova, Marius Ardeleanu, Laurent Eckert, Zafer E. Ozturk

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Insights into the real-world treatment paradigm and long-term burden of atopic dermatitis (AD) are needed to inform clinical and health policy decisions. Methods: The prospective, observational EUROSTAD study enrolled adults with moderate-to-severe AD starting or switching systemic therapy (51 sites in 10 European countries). We report the baseline characteristics, treatment patterns, and outcomes of these patients using descriptive statistics. Results: A 12-month enrollment period of EUROSTAD was completed and 308 patients were enrolled: average age 37 years, AD duration 25 years, 43% were female. Most patients reported use of systemic therapy (93%) and ≥1 atopic comorbidity (82%). Mean [standard deviation] disease severity/burden measures were high: Investigator’s Global Assessment (3.1 [0.8]), Eczema Area and Severity Index (16.2 [10.9]), Peak Pruritus Numerical Rating Scale (5.5 [2.5]), sleep impairment Visual Analog Scale (49.8 [31.6]) scores, and time lost from work (4.1 [13.7] days/year) or usual activities (16.8 [38.7] days/year). Most patients showed borderline or clinical levels of anxiety (59%) and/or depression (63%) using the Hospital Anxiety and Depression Scale. Conclusions: Adults with moderate-to-severe AD starting/switching systemic treatment enrolled in EUROSTAD have a high burden of longstanding disease despite continuous use of topical drugs, emollients, and systemic therapies.

Original languageEnglish
Pages (from-to)164-173
Number of pages10
JournalJournal of Dermatological Treatment
Volume32
Issue number2
DOIs
Publication statusPublished - 2021

Keywords

  • Atopic dermatitis
  • patient-reported outcomes
  • quality of life
  • systemic therapy

ASJC Scopus subject areas

  • Dermatology

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