Disease history in 382 Italian patients with Crohn's disease

G. Vannozzi, R. Fontana, M. Milla, A. G. Bonanomi, G. Trallori, M. Gabbrielli, F. Pacini, G. Leandro, A. Morettini

Research output: Contribution to journalArticlepeer-review


Aims. This large-scale study was aimed at evaluating the long-term history of Crohn's disease in a cohort of consecutive patients referred to the Careggi Hospital in Florence from January 1973 to June 1996. Patients. A total of 382 patients (187 females, 195 males; mean age of 47 years) were included in our study. The median follow-up was more than 11 years and only 46 patients (12%) had a follow-up of less than 1 year. The main endpoints evaluated in these patients included mortality for any cause, disease-specific mortality, recurrences, and need for surgery. Furthermore, in a subgroup of 130 patients observed during the last 6 months of our study, a more detailed assessment of the disease was carried out in which the distribution of inflammatory, fibrostenosing and fistulizing forms was determined. Results. Our results showed that the disease-specific mortality rate was extremely low (around 3% at 10 years and 5% at 20 years), but the rate of recurrence was approximately 50% at 3 years and more than 60% at 6 years. Surgery was needed in more than 50% of the patients over the 10 years following diagnosis, and the risk of a second operation was of a further 30% within 4 years of the first operation. Conclusions. These epidemiological data emerging from our study are interesting since a large patient population was evaluated and the duration of the follow-up is extremely long.

Original languageEnglish
Pages (from-to)525-532
Number of pages8
JournalItalian Journal of Gastroenterology and Hepatology
Issue number6
Publication statusPublished - 1997


  • Crohn's disease
  • Indications for surgery
  • Natural history
  • Recurrence

ASJC Scopus subject areas

  • Gastroenterology


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