Disease history in 382 Italian patients with Crohn's disease

G. Vannozzi, R. Fontana, M. Milla, A. G. Bonanomi, G. Trallori, M. Gabbrielli, F. Pacini, G. Leandro, A. Morettini

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aims. This large-scale study was aimed at evaluating the long-term history of Crohn's disease in a cohort of consecutive patients referred to the Careggi Hospital in Florence from January 1973 to June 1996. Patients. A total of 382 patients (187 females, 195 males; mean age of 47 years) were included in our study. The median follow-up was more than 11 years and only 46 patients (12%) had a follow-up of less than 1 year. The main endpoints evaluated in these patients included mortality for any cause, disease-specific mortality, recurrences, and need for surgery. Furthermore, in a subgroup of 130 patients observed during the last 6 months of our study, a more detailed assessment of the disease was carried out in which the distribution of inflammatory, fibrostenosing and fistulizing forms was determined. Results. Our results showed that the disease-specific mortality rate was extremely low (around 3% at 10 years and 5% at 20 years), but the rate of recurrence was approximately 50% at 3 years and more than 60% at 6 years. Surgery was needed in more than 50% of the patients over the 10 years following diagnosis, and the risk of a second operation was of a further 30% within 4 years of the first operation. Conclusions. These epidemiological data emerging from our study are interesting since a large patient population was evaluated and the duration of the follow-up is extremely long.

Original languageEnglish
Pages (from-to)525-532
Number of pages8
JournalItalian Journal of Gastroenterology and Hepatology
Volume29
Issue number6
Publication statusPublished - 1997

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Crohn Disease
Mortality
Recurrence
Population

Keywords

  • Crohn's disease
  • Indications for surgery
  • Natural history
  • Recurrence

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Vannozzi, G., Fontana, R., Milla, M., Bonanomi, A. G., Trallori, G., Gabbrielli, M., ... Morettini, A. (1997). Disease history in 382 Italian patients with Crohn's disease. Italian Journal of Gastroenterology and Hepatology, 29(6), 525-532.

Disease history in 382 Italian patients with Crohn's disease. / Vannozzi, G.; Fontana, R.; Milla, M.; Bonanomi, A. G.; Trallori, G.; Gabbrielli, M.; Pacini, F.; Leandro, G.; Morettini, A.

In: Italian Journal of Gastroenterology and Hepatology, Vol. 29, No. 6, 1997, p. 525-532.

Research output: Contribution to journalArticle

Vannozzi, G, Fontana, R, Milla, M, Bonanomi, AG, Trallori, G, Gabbrielli, M, Pacini, F, Leandro, G & Morettini, A 1997, 'Disease history in 382 Italian patients with Crohn's disease', Italian Journal of Gastroenterology and Hepatology, vol. 29, no. 6, pp. 525-532.
Vannozzi G, Fontana R, Milla M, Bonanomi AG, Trallori G, Gabbrielli M et al. Disease history in 382 Italian patients with Crohn's disease. Italian Journal of Gastroenterology and Hepatology. 1997;29(6):525-532.
Vannozzi, G. ; Fontana, R. ; Milla, M. ; Bonanomi, A. G. ; Trallori, G. ; Gabbrielli, M. ; Pacini, F. ; Leandro, G. ; Morettini, A. / Disease history in 382 Italian patients with Crohn's disease. In: Italian Journal of Gastroenterology and Hepatology. 1997 ; Vol. 29, No. 6. pp. 525-532.
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