Disease persistence in patients with cervical intraepithelial neoplasia undergoing electrosurgical conization

Silvano Costa, Maria De Nuzzo, Fanny E. Infante, Benedetta Bonavita, Marica Marinelli, Anna Rubino, Valeria Rambelli, Donatella Santini, Paolo Cristiani, Lauro Bucchi

Research output: Contribution to journalArticlepeer-review


Objective. Cone margin status has been reported to be the most important predictor of residual disease in patients with cervical intraepithelial neoplasia (CIN) undergoing electrosurgical excisional treatment. The primary aim of this study of patients treated with electrosurgical conization was to evaluate the association of cone margin status and other clinical and pathologic factors with the probability of residual disease. Methods. The study population comprised 699 patients with at least one follow-up visit within 12 months of conization. Residual disease was defined as a histology diagnosis of CIN within 3 years of conization. Multivariate associations were evaluated with multiple logistic regression analysis. Results. Attendance to follow-up was 97% for the second visit and 34% for the third visit. Residual disease was detected in a total of 38 patients (5.4%). The detection rate was 3.3% at the first visit, 2.1% at the second visit, and 0.4% at the third visit. An increased probability of residual disease was associated with a referral Pap smear reported as high-grade squamous intraepithelial neoplasia and carcinoma (odds ratio, 2.9; reference category, low-grade squamous intraepithelial neoplasia). A decreased probability was associated with a squamocolumnar junction entirely visible at the first follow-up visit (odds ratio, 0.2; reference category, squamocolumnar junction not visible). Patient age, time period, lesion size, lesion site, grade of CIN, cone width, cone depth, and margin status had no influence. Conclusions. The determinants of residual disease in this study differed from those generally reported so far. Factors associated with effectiveness of electrosurgical treatment of CIN need further research.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalGynecologic Oncology
Issue number1
Publication statusPublished - 2002


  • Cervical cone margins
  • Cervical intraepithelial neoplasia
  • Electrosurgical conization
  • Follow-up
  • Residual disease

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology


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