Disease progression or pseudoprogression after concomitant radiochemotherapy treatment: Pitfalls in neurooncology

Alba A. Brandes, Alicia Tosoni, Federica Spagnolli, Giampiero Frezza, Marco Leonardi, Fabio Calbucci, Enrico Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

Although radionecrosis has been exhaustively described in depth in the neurooncological literature, its diagnosis is still a challenging issue because its radiological pattern is frequently indistinguishable from that of tumor recurrence. This review discusses the causes of radionecrosis and the potential effect of adjuvant chemotherapy concomitant with radiotherapy on its rate and onset. The potential pitfalls in clinical studies attempting to make a differential diagnosis between radionecrosis and disease progression are also discussed.

Original languageEnglish
Pages (from-to)361-367
Number of pages7
JournalNeuro-Oncology
Volume10
Issue number3
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Chemotherapy
  • Glioma
  • Pseudoprogression
  • Radionecrosis
  • Radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Clinical Neurology

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