From 1986 until today 32 patients with metastatic bladder cancer were treated by Cisplatin, Methotrexate and Vinblastine (CMV) chemotherapy. We divided these patients into three groups: 13 patients with disease relapse after neoadjuvant CMV chemotherapy and radical cystectomy (group A); 11 pts with disease relapse after radical cystectomy alone (group B) and 8 pts. with metastatic bladder cancer as first clinical observation and not surgically pretreated (group C). We performed a total of 88 cycles, in accordance with Harker's schedule, because 8 pts. stopped chemotherapy for heavy toxicity(2 deaths). Median survival was 9.8 months in group A, 16.9 months in group B and 6.3 months in group C. In our opinion, the efficacy of chemotherapy is greater in patients who have never undergone this treatment before than in those where a neoadjuvant therapy has been performed. Probably it depends upon the heavy cumulative toxicity and selection of chemoresistant cellular clones.
|Number of pages||3|
|Journal||Acta Urologica Italica|
|Publication status||Published - 1998|
- Bladder cancer
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