Disentangling cardiovascular control mechanisms during head-down tilt via joint transfer entropy and self-entropy decompositions

Alberto Porta, Luca Faes, Andrea Marchi, Vlasta Bari, Beatrice De Maria, Stefano Guzzetti, Riccardo Colombo, Ferdinando Raimondi

Research output: Contribution to journalArticle

Abstract

A full decomposition of the predictive entropy (PE) of the spontaneous variations of the heart period (HP) given systolic arterial pressure (SAP) and respiration (R) is proposed. The PE of HP is decomposed into the joint transfer entropy (JTE) from SAP and R to HP and self-entropy (SE) of HP. The SE is the sum of three terms quantifying the synergistic/redundant contributions of HP and SAP, when taken individually and jointly, to SE and one term conditioned on HP and SAP denoted as the conditional SE (CSE) of HP given SAP and R. The JTE from SAP and R to HP is the sum of two terms attributable to SAP or R plus an extra term describing the redundant/synergistic contribution to the JTE. All quantities were computed during cardiopulmonary loading induced by -25° head-down tilt (HDT) via a multivariate linear regression approach. We found that: (i) the PE of HP decreases during HDT; (ii) the decrease of PE is attributable to a lessening of SE of HP, while the JTE from SAP and R to HP remains constant; (iii) the SE of HP is dominant over the JTE from SAP and R to HP and the CSE of HP given SAP and R is prevailing over the SE of HP due to SAP and R both in supine position and during HDT; (iv) all terms of the decompositions of JTE from SAP and R to HP and SE of HP due to SAP and R were not affected by HDT; (v) the decrease of the SE of HP during HDT was attributed to the reduction of the CSE of HP given SAP and R; (vi) redundancy of SAP and R is prevailing over synergy in the information transferred into HP both in supine position and during HDT, while in the HP information storage synergy and redundancy are more balanced. The approach suggests that the larger complexity of the cardiac control during HDT is unrelated to the baroreflex control and cardiopulmonary reflexes and may be related to central commands and/or modifications of the dynamical properties of the sinus node.

Original languageEnglish
Article number301
JournalFrontiers in Physiology
Volume6
Issue numberOCT
DOIs
Publication statusPublished - 2015

Keywords

  • Autonomic nervous system
  • Baroreflex
  • Blood pressure variability
  • Cardiopulmonary coupling
  • Heart rate variability
  • Information dynamics
  • Multivariate linear regression analysis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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