Disentangling the roles of mammographic screening and HRT in recent breast cancer incidence trends in italy by analyses based on calendar time and time since screening activation

Emanuele Crocetti, Carlotta Buzzoni, Fabio Falcini, Laura Cortesi, Vincenzo De Lisi, Stefano Ferretti, Rosario Tumino, Antonio Russo, Eugenio Paci

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The aim of the study was to evaluate the roles of screening activation and hormone replacement therapy discontinuation on the recent declining breast cancer incidence trends in Italy. We analyzed 41,358 invasive female breast cancers incident during 1991-2004 in six Italian population-based cancer registries. Overall and age-specific incidence trends were evaluated using Joinpoint analysis. In addition to calendar years, data were analyzed on a years-since-screening- activation basis. Annual percentage change of standardized rates was computed. There were statistically significant increasing trends for women 40-44 and 45-49 years that did not change after screening activation. On the contrary, for women 50-69 years old and for those 70+ years, the increasing trends flattened around 2 years after screening activation. The prevalence of hormone replacement therapy use in Italy is and was rather low. In conclusion, the recent tendency toward stabilization observed in Italy for female breast cancer incidence rates in women aged 50 years or more follows the introduction of mammographic screening.

Original languageEnglish
Pages (from-to)350-355
Number of pages6
JournalBreast Journal
Volume16
Issue number4
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Italy
Hormone Replacement Therapy
Breast Neoplasms
Incidence
Registries
Population
Calendars
Neoplasms

Keywords

  • Breast cancer
  • Hormone replacement therapy
  • Incidence
  • Population-based
  • Screening

ASJC Scopus subject areas

  • Internal Medicine
  • Oncology
  • Surgery

Cite this

Disentangling the roles of mammographic screening and HRT in recent breast cancer incidence trends in italy by analyses based on calendar time and time since screening activation. / Crocetti, Emanuele; Buzzoni, Carlotta; Falcini, Fabio; Cortesi, Laura; Lisi, Vincenzo De; Ferretti, Stefano; Tumino, Rosario; Russo, Antonio; Paci, Eugenio.

In: Breast Journal, Vol. 16, No. 4, 07.2010, p. 350-355.

Research output: Contribution to journalArticle

Crocetti, Emanuele ; Buzzoni, Carlotta ; Falcini, Fabio ; Cortesi, Laura ; Lisi, Vincenzo De ; Ferretti, Stefano ; Tumino, Rosario ; Russo, Antonio ; Paci, Eugenio. / Disentangling the roles of mammographic screening and HRT in recent breast cancer incidence trends in italy by analyses based on calendar time and time since screening activation. In: Breast Journal. 2010 ; Vol. 16, No. 4. pp. 350-355.
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