DISNOR: A disease network open resource

Prisca Lo Surdo, Alberto Calderone, Marta Iannuccelli, Luana Licata, Daniele Peluso, Luisa Castagnoli, Gianni Cesareni, Livia Perfetto

Research output: Contribution to journalArticle

Abstract

DISNOR is a new resource that aims at exploiting the explosion of data on the identification of disease-associated genes to assemble inferred disease pathways. This may help dissecting the signaling events whose disruption causes the pathological phenotypes and may contribute to build a platform for precision medicine. To this end we combine the gene-disease association (GDA) data annotated in the DisGeNET resource with a new curation effort aimed at populating the SIGNOR database with causal interactions related to disease genes with the highest possible coverage. DISNOR can be freely accessed at http://DISNOR.uniroma2.it/ where >3700 disease-networks, linking 1/42600 disease genes, can be explored. For each disease curated in DisGeNET, DISNOR links disease genes by manually annotated causal relationships and offers an intuitive visualization of the inferred 'patho-pathways' at different complexity levels. User-defined gene lists are also accepted in the query pipeline. In addition, for each list of query genes - either annotated in DisGeNET or user-defined - DISNOR performs a gene set enrichment analysis on KEGG-defined pathways or on the lists of proteins associated with the inferred disease pathways. This function offers additional information on disease-associated cellular pathways and disease similarity.

Original languageEnglish
Pages (from-to)D527-D534
JournalNucleic Acids Research
Volume46
Issue numberD1
DOIs
Publication statusE-pub ahead of print - Oct 3 2017

ASJC Scopus subject areas

  • Genetics

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    Lo Surdo, P., Calderone, A., Iannuccelli, M., Licata, L., Peluso, D., Castagnoli, L., Cesareni, G., & Perfetto, L. (2017). DISNOR: A disease network open resource. Nucleic Acids Research, 46(D1), D527-D534. https://doi.org/10.1093/nar/gkx876