Disodium cromoglycate versus diet in the treatment and prevention of nickel-positive pompholyx

P. D. Pigatto, E. Gibelli, M. Fumagalli, A. Bigardi, M. Morelli, G. F. Altomare

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In some cases that have been diagnosed as contact allergy to nickel, there are repeated cutaneous eruptions of pompholyx, even in areas with no direct contact with the metal. The possible alimentary origin of dyshidrotic eczema should be considered when deciding on therapy. We have collected the clinical data for 24 patients with dyshidrotic eczema caused by nickel, to evaluate the benefit of a low-nickel diet versus treatment with oral disodium cromoglycate, comparing both objective and subjective symptoms. A low-nickel dietdoes not improve these patients but those treated with DSCG reacted better from both objective and subjective point of view, than either the controls or the patients treated by diet. We next did intestinal permeability tests before therapy and after 15 days of treatment. We found that nickel uptake diminishes simultaneously with the reduction of absorption through the smaller aqueous 'pores'. This phenomenon was greatest after DSCG. We suggest that DSCG can help selected cases of pompholyx.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalContact Dermatitis
Issue number1
Publication statusPublished - 1990


  • Disodium cromoglycate
  • Dyshidrotic eczema
  • Low nickel diet
  • Nickel
  • Pompholyx

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Toxicology


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