Disordered pupil reactivity in Parkinson's disease

Giuseppe Micieli, Cristina Tassorelli, Emilia Martignoni, Claudio Pacchetti, Patrizia Bruggi, Marco Magri, Giuseppe Nappi

Research output: Contribution to journalArticlepeer-review


Different varieties of pupillary abnormalities have been described in Parkinson's disease but it is not clear if this is due to the disease itself or to the pharmacological treatment. In this study, pupil reactivity to various stimuli (dark/light adaptation, light reflex, near vision reaction and electrical sural stimulation) was investigated in 23 de novo parkinsonian patients (not on drugs) to assess pupillary abnormalities and investigate their pathophysiological mechanisms. Parkinsonian patients exhibited larger pupil diameter after light adaptation, as well as a reduced amplitude of contraction and a prolonged contraction time at light reflex. The data obtained confirmed the existence in Parkinson's disease of a pupillary imbalance mainly involving the parasymapathetic system.

Original languageEnglish
Pages (from-to)55-58
Number of pages4
JournalClinical Autonomic Research
Issue number1
Publication statusPublished - Mar 1991


  • Parkinson's disease
  • Pupil reactivity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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