Abstract
Endocrine functions in 7 cases of primary empty sella were studied. No clinical features of endocrine disturbances were apparent. Urinary excretion of gonadotropins, and thyroid and adrenal functions were normal. Plasma human growth hormone (HGH) concentration was also normal but did not increase after insulin induced hypoglycemia in 4 patients, after arginine in one, and after a glucose load in 6. Urinary excretion of 17 hydroxycorticosteroids (17 OHCS) increased normally in all patients after metyrapone administration, while plasma 17 OHCS did not increase in 3 subjects after insulin induced hypoglycemia or in one after lysine vasopressin. Two patients showed exaggerated responses to lysine vasopressin. These results indicate an impairment of the hypothalamic HGH and corticotropin regulation in patients with empty sella. Since in chromophobe adenomas comparable changes were seen, the differential diagnosis between empty sella and chromophobe adenoma is impossible on the basis of endocrinological data alone. The only reliable diagnostic method is accurate radiological study including air contrast tomoencephalography.
| Original language | English |
|---|---|
| Pages (from-to) | 59-64 |
| Number of pages | 6 |
| Journal | Journal of Neurosurgery |
| Volume | 38 |
| Issue number | 1 |
| Publication status | Published - 1973 |
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ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Disorders of growth hormone and corticotropin regulation in patients with empty sella. / Faglia, G.; Ambrosi, B.; Beck Peccoz, P.; Giovanelli, M.
In: Journal of Neurosurgery, Vol. 38, No. 1, 1973, p. 59-64.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Disorders of growth hormone and corticotropin regulation in patients with empty sella
AU - Faglia, G.
AU - Ambrosi, B.
AU - Beck Peccoz, P.
AU - Giovanelli, M.
PY - 1973
Y1 - 1973
N2 - Endocrine functions in 7 cases of primary empty sella were studied. No clinical features of endocrine disturbances were apparent. Urinary excretion of gonadotropins, and thyroid and adrenal functions were normal. Plasma human growth hormone (HGH) concentration was also normal but did not increase after insulin induced hypoglycemia in 4 patients, after arginine in one, and after a glucose load in 6. Urinary excretion of 17 hydroxycorticosteroids (17 OHCS) increased normally in all patients after metyrapone administration, while plasma 17 OHCS did not increase in 3 subjects after insulin induced hypoglycemia or in one after lysine vasopressin. Two patients showed exaggerated responses to lysine vasopressin. These results indicate an impairment of the hypothalamic HGH and corticotropin regulation in patients with empty sella. Since in chromophobe adenomas comparable changes were seen, the differential diagnosis between empty sella and chromophobe adenoma is impossible on the basis of endocrinological data alone. The only reliable diagnostic method is accurate radiological study including air contrast tomoencephalography.
AB - Endocrine functions in 7 cases of primary empty sella were studied. No clinical features of endocrine disturbances were apparent. Urinary excretion of gonadotropins, and thyroid and adrenal functions were normal. Plasma human growth hormone (HGH) concentration was also normal but did not increase after insulin induced hypoglycemia in 4 patients, after arginine in one, and after a glucose load in 6. Urinary excretion of 17 hydroxycorticosteroids (17 OHCS) increased normally in all patients after metyrapone administration, while plasma 17 OHCS did not increase in 3 subjects after insulin induced hypoglycemia or in one after lysine vasopressin. Two patients showed exaggerated responses to lysine vasopressin. These results indicate an impairment of the hypothalamic HGH and corticotropin regulation in patients with empty sella. Since in chromophobe adenomas comparable changes were seen, the differential diagnosis between empty sella and chromophobe adenoma is impossible on the basis of endocrinological data alone. The only reliable diagnostic method is accurate radiological study including air contrast tomoencephalography.
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M3 - Article
C2 - 4345170
AN - SCOPUS:0015795507
VL - 38
SP - 59
EP - 64
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
SN - 0022-3085
IS - 1
ER -