Disorders of nuclear-mitochondrial intergenomic communication

Antonella Spinazzola; Massimo Zeviani

doi:10.1007/s10540-007-9036-1

Disorders of nuclear-mitochondrial intergenomic communication

Antonella Spinazzola, Massimo Zeviani

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

In the course of evolution, mitochondria lost their independence, and mtDNA became "slave" of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integrity or expression, being inherited as mendelian traits.

Original language	English
Pages (from-to)	39-51
Number of pages	13
Journal	Bioscience Reports
Volume	27
Issue number	1-3
DOIs	https://doi.org/10.1007/s10540-007-9036-1
Publication status	Published - Jun 2007

Keywords

Mitochondrial disease
Mitochondrial DNA
mtDNA depletion
mtDNA multiple deletions
Nucleus-mitochondrion cross-talk

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Cell Biology

Access to Document

10.1007/s10540-007-9036-1

Cite this

@article{0d30d0f68b474d66a3d4eebf06f15192,

title = "Disorders of nuclear-mitochondrial intergenomic communication",

abstract = "In the course of evolution, mitochondria lost their independence, and mtDNA became {"}slave{"} of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integrity or expression, being inherited as mendelian traits.",

keywords = "Mitochondrial disease, Mitochondrial DNA, mtDNA depletion, mtDNA multiple deletions, Nucleus-mitochondrion cross-talk",

author = "Antonella Spinazzola and Massimo Zeviani",

year = "2007",

month = jun,

doi = "10.1007/s10540-007-9036-1",

language = "English",

volume = "27",

pages = "39--51",

journal = "Bioscience Reports",

issn = "0144-8463",

publisher = "Portland Press Ltd.",

number = "1-3",

}

TY - JOUR

T1 - Disorders of nuclear-mitochondrial intergenomic communication

AU - Spinazzola, Antonella

AU - Zeviani, Massimo

PY - 2007/6

Y1 - 2007/6

N2 - In the course of evolution, mitochondria lost their independence, and mtDNA became "slave" of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integrity or expression, being inherited as mendelian traits.

AB - In the course of evolution, mitochondria lost their independence, and mtDNA became "slave" of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integrity or expression, being inherited as mendelian traits.

KW - Mitochondrial disease

KW - Mitochondrial DNA

KW - mtDNA depletion

KW - mtDNA multiple deletions

KW - Nucleus-mitochondrion cross-talk

UR - http://www.scopus.com/inward/record.url?scp=34250662313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250662313&partnerID=8YFLogxK

U2 - 10.1007/s10540-007-9036-1

DO - 10.1007/s10540-007-9036-1

M3 - Article

C2 - 17510790

AN - SCOPUS:34250662313

VL - 27

SP - 39

EP - 51

JO - Bioscience Reports

JF - Bioscience Reports

SN - 0144-8463

IS - 1-3

ER -

Disorders of nuclear-mitochondrial intergenomic communication

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this