Disorders of nuclear-mitochondrial intergenomic communication

Antonella Spinazzola, Massimo Zeviani

Research output: Contribution to journalArticlepeer-review


In the course of evolution, mitochondria lost their independence, and mtDNA became "slave" of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integrity or expression, being inherited as mendelian traits.

Original languageEnglish
Pages (from-to)39-51
Number of pages13
JournalBioscience Reports
Issue number1-3
Publication statusPublished - Jun 2007


  • Mitochondrial disease
  • Mitochondrial DNA
  • mtDNA depletion
  • mtDNA multiple deletions
  • Nucleus-mitochondrion cross-talk

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology


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