Disorders of nuclear-mitochondrial intergenomic communication

Antonella Spinazzola; Massimo Zeviani

doi:10.1007/s10540-007-9036-1

Disorders of nuclear-mitochondrial intergenomic communication

Antonella Spinazzola, Massimo Zeviani

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article

Abstract

In the course of evolution, mitochondria lost their independence, and mtDNA became "slave" of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integrity or expression, being inherited as mendelian traits.

Original language	English
Pages (from-to)	39-51
Number of pages	13
Journal	Bioscience Reports
Volume	27
Issue number	1-3
DOIs	https://doi.org/10.1007/s10540-007-9036-1
Publication status	Published - Jun 2007

Keywords

Mitochondrial disease
Mitochondrial DNA
mtDNA depletion
mtDNA multiple deletions
Nucleus-mitochondrion cross-talk

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Cell Biology

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Spinazzola, A., & Zeviani, M. (2007). Disorders of nuclear-mitochondrial intergenomic communication. Bioscience Reports, 27(1-3), 39-51. https://doi.org/10.1007/s10540-007-9036-1

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