Abstract
In the course of evolution, mitochondria lost their independence, and mtDNA became "slave" of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integrity or expression, being inherited as mendelian traits.
Original language | English |
---|---|
Pages (from-to) | 39-51 |
Number of pages | 13 |
Journal | Bioscience Reports |
Volume | 27 |
Issue number | 1-3 |
DOIs | |
Publication status | Published - Jun 2007 |
Keywords
- Mitochondrial disease
- Mitochondrial DNA
- mtDNA depletion
- mtDNA multiple deletions
- Nucleus-mitochondrion cross-talk
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology