Disorders of Ventral Induction/Spectrum of Holoprosencephaly

Sonia Francesca Calloni, Luca Caschera, Fabio Maria Triulzi

Research output: Contribution to journalReview article

Abstract

Disorders of the ventral induction give rise to a group of congenital malformations that share in common the failure of the prosencephalon cleavage and subsequent formation of midline structures, presenting with a wide spectrum of severity. This article focuses on the imaging findings of the holoprosencephaly spectrum and septo-optic dysplasia, their epidemiology, embryology, and the common clinical associated anomalies. Knowledge of the imaging features of these disorders is necessary for a correct interpretation of findings and accurate parental counseling. Diagnostic evaluation of patients should include molecular screening and genetic counseling to characterize prognosis and risk of recurrence.

Original languageEnglish
Pages (from-to)411-421
Number of pages11
JournalNeuroimaging Clinics of North America
Volume29
Issue number3
DOIs
Publication statusPublished - Aug 1 2019

Fingerprint

Septo-Optic Dysplasia
Holoprosencephaly
Embryology
Genetic Counseling
Prosencephalon
Counseling
Molecular Biology
Epidemiology
Recurrence

Keywords

  • Brain
  • Holoprosencephaly
  • Magnetic resonance
  • Neurodevelopment
  • Syntelencephaly
  • Ventral induction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Disorders of Ventral Induction/Spectrum of Holoprosencephaly. / Calloni, Sonia Francesca; Caschera, Luca; Triulzi, Fabio Maria.

In: Neuroimaging Clinics of North America, Vol. 29, No. 3, 01.08.2019, p. 411-421.

Research output: Contribution to journalReview article

Calloni, Sonia Francesca ; Caschera, Luca ; Triulzi, Fabio Maria. / Disorders of Ventral Induction/Spectrum of Holoprosencephaly. In: Neuroimaging Clinics of North America. 2019 ; Vol. 29, No. 3. pp. 411-421.
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