TY - JOUR
T1 - Dispersion of ventricular repolarization in the long QT syndrome
AU - De Ambroggi, Luigi
AU - Negroni, Maria S.
AU - Monza, Emanuela
AU - Bertoni, Tito
AU - Schwartz, Peter J.
PY - 1991/9/1
Y1 - 1991/9/1
N2 - To identify markers of dispersion of the ventricular repolarization in the idiopathic long QT syndrome, body surface potential maps were analyzed in 40 such patients (mean age ± standard deviation 21 ± 11 years) and in 30 healthy control subjects (mean age 24 ± 7 years). In each subject, 117 chest leads were recorded and maps of the integral values of the QRST interval were calculated. A multipolar distribution of the values, a marker of gross electrical inequalities of repolarization, was found only in 4 patients. To detect minor regional disparities of ventricular recovery, all the ST-T waveforms were analyzed in each subject. The ST-T waves were represented by a discrete series of potential values. The "similarity index" was computed by applying a principal component analysis, which represents (in percent) to what extent 1 fundamental pattern of ST-T reproduces all the recorded waveforms. The mean value of the similarity index was significantly lower in patients with long QT syndrome than in control subjects (49 ± 10 vs 77 ± 8%, p <0.0001). A value
AB - To identify markers of dispersion of the ventricular repolarization in the idiopathic long QT syndrome, body surface potential maps were analyzed in 40 such patients (mean age ± standard deviation 21 ± 11 years) and in 30 healthy control subjects (mean age 24 ± 7 years). In each subject, 117 chest leads were recorded and maps of the integral values of the QRST interval were calculated. A multipolar distribution of the values, a marker of gross electrical inequalities of repolarization, was found only in 4 patients. To detect minor regional disparities of ventricular recovery, all the ST-T waveforms were analyzed in each subject. The ST-T waves were represented by a discrete series of potential values. The "similarity index" was computed by applying a principal component analysis, which represents (in percent) to what extent 1 fundamental pattern of ST-T reproduces all the recorded waveforms. The mean value of the similarity index was significantly lower in patients with long QT syndrome than in control subjects (49 ± 10 vs 77 ± 8%, p <0.0001). A value
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U2 - 10.1016/0002-9149(91)90353-M
DO - 10.1016/0002-9149(91)90353-M
M3 - Article
C2 - 1877478
AN - SCOPUS:0026052302
VL - 68
SP - 614
EP - 620
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 6
ER -