Dispersion of ventricular repolarization in the long QT syndrome

Luigi De Ambroggi, Maria S. Negroni, Emanuela Monza, Tito Bertoni, Peter J. Schwartz

Research output: Contribution to journalArticlepeer-review


To identify markers of dispersion of the ventricular repolarization in the idiopathic long QT syndrome, body surface potential maps were analyzed in 40 such patients (mean age ± standard deviation 21 ± 11 years) and in 30 healthy control subjects (mean age 24 ± 7 years). In each subject, 117 chest leads were recorded and maps of the integral values of the QRST interval were calculated. A multipolar distribution of the values, a marker of gross electrical inequalities of repolarization, was found only in 4 patients. To detect minor regional disparities of ventricular recovery, all the ST-T waveforms were analyzed in each subject. The ST-T waves were represented by a discrete series of potential values. The "similarity index" was computed by applying a principal component analysis, which represents (in percent) to what extent 1 fundamental pattern of ST-T reproduces all the recorded waveforms. The mean value of the similarity index was significantly lower in patients with long QT syndrome than in control subjects (49 ± 10 vs 77 ± 8%, p <0.0001). A value

Original languageEnglish
Pages (from-to)614-620
Number of pages7
JournalThe American Journal of Cardiology
Issue number6
Publication statusPublished - Sep 1 1991

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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