Abstract
Objective: To investigate the pharmacokinetics and pharmacodynamics of liposomal daunombicin (DaunoXome™) 80 or 100 mg/m2 on days 1, 2 and 3 coadministered with standard or high-dose cytarabine to patients with poor-risk acute leukaemia. Design: Unblinded pharmacokinetic-pharmacodynamic study. Participants: Twenty-three adult patients with acute leukaemia. Methods: Blood, bone marrow and urine samples were collected at appropriate intervals on days 1-6. Total daunombicin and daunombicinol concentrations in plasma, bone marrow, peripheral blood cells and urine were measured by high performance liquid chromatography. Results: Liposomal daunorubicin exhibited a markedly different pharmacokinetic behaviour from the free drug due to a slow distribution of the liposomal moiety into the body. The ratio of area under the concentration-time curve (AUC) for metabolite to parent drug was lower for liposomal daunombicin than for free daunombicin, mainly due to higher concentrations of the parent drug in plasma, whereas daunombicinol exposure was more or less comparable, if not higher. After liposomal daunorubicin at both 80 and 100 mg/m2, total daunorubicin concentrations in leukaemic cells were at least similar to those observed for free daunorubicin, and significant accumulation was also observed in bone marrow blast cells. Nineteen of 23 patients obtained a complete remission, although 13 had P-glycoprotein-overexpressing blast cells. Grade 3-4 mucositis was found only in three patients with very high AUCs for total daunorubicin and daunorubicinol. Conclusions: Liposomal daunorubicin at both 80 and 100 mg/m2 in combination with cytarabine may represent a valid treatment for high-risk acute leukaemia. Liposomal daunorubicin may be helpful in overcoming multidrug resistance, since it shows significant accumulation into tumour target cells, irrespective of P-glycoprotein expression. The tolerability profile suggests that toxicity may be related to exposure to both the parent drug and the metabolite.
| Original language | English |
|---|---|
| Pages (from-to) | 851-862 |
| Number of pages | 12 |
| Journal | Clinical Pharmacokinetics |
| Volume | 42 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2003 |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
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Disposition of liposomal daunorubicin during cotreatment with cytarabine in patients with leukaemia. / Pea, Federico; Russo, Domenico; Michieli, Mariagrazia; Damiani, Daniela; Fanin, Renato; Michelutti, Angela; Michelutti, Teresa; Piccolrovazzi, Stefano; Baccarani, Michele; Furlanut, Mario.
In: Clinical Pharmacokinetics, Vol. 42, No. 9, 2003, p. 851-862.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Disposition of liposomal daunorubicin during cotreatment with cytarabine in patients with leukaemia
AU - Pea, Federico
AU - Russo, Domenico
AU - Michieli, Mariagrazia
AU - Damiani, Daniela
AU - Fanin, Renato
AU - Michelutti, Angela
AU - Michelutti, Teresa
AU - Piccolrovazzi, Stefano
AU - Baccarani, Michele
AU - Furlanut, Mario
PY - 2003
Y1 - 2003
N2 - Objective: To investigate the pharmacokinetics and pharmacodynamics of liposomal daunombicin (DaunoXome™) 80 or 100 mg/m2 on days 1, 2 and 3 coadministered with standard or high-dose cytarabine to patients with poor-risk acute leukaemia. Design: Unblinded pharmacokinetic-pharmacodynamic study. Participants: Twenty-three adult patients with acute leukaemia. Methods: Blood, bone marrow and urine samples were collected at appropriate intervals on days 1-6. Total daunombicin and daunombicinol concentrations in plasma, bone marrow, peripheral blood cells and urine were measured by high performance liquid chromatography. Results: Liposomal daunorubicin exhibited a markedly different pharmacokinetic behaviour from the free drug due to a slow distribution of the liposomal moiety into the body. The ratio of area under the concentration-time curve (AUC) for metabolite to parent drug was lower for liposomal daunombicin than for free daunombicin, mainly due to higher concentrations of the parent drug in plasma, whereas daunombicinol exposure was more or less comparable, if not higher. After liposomal daunorubicin at both 80 and 100 mg/m2, total daunorubicin concentrations in leukaemic cells were at least similar to those observed for free daunorubicin, and significant accumulation was also observed in bone marrow blast cells. Nineteen of 23 patients obtained a complete remission, although 13 had P-glycoprotein-overexpressing blast cells. Grade 3-4 mucositis was found only in three patients with very high AUCs for total daunorubicin and daunorubicinol. Conclusions: Liposomal daunorubicin at both 80 and 100 mg/m2 in combination with cytarabine may represent a valid treatment for high-risk acute leukaemia. Liposomal daunorubicin may be helpful in overcoming multidrug resistance, since it shows significant accumulation into tumour target cells, irrespective of P-glycoprotein expression. The tolerability profile suggests that toxicity may be related to exposure to both the parent drug and the metabolite.
AB - Objective: To investigate the pharmacokinetics and pharmacodynamics of liposomal daunombicin (DaunoXome™) 80 or 100 mg/m2 on days 1, 2 and 3 coadministered with standard or high-dose cytarabine to patients with poor-risk acute leukaemia. Design: Unblinded pharmacokinetic-pharmacodynamic study. Participants: Twenty-three adult patients with acute leukaemia. Methods: Blood, bone marrow and urine samples were collected at appropriate intervals on days 1-6. Total daunombicin and daunombicinol concentrations in plasma, bone marrow, peripheral blood cells and urine were measured by high performance liquid chromatography. Results: Liposomal daunorubicin exhibited a markedly different pharmacokinetic behaviour from the free drug due to a slow distribution of the liposomal moiety into the body. The ratio of area under the concentration-time curve (AUC) for metabolite to parent drug was lower for liposomal daunombicin than for free daunombicin, mainly due to higher concentrations of the parent drug in plasma, whereas daunombicinol exposure was more or less comparable, if not higher. After liposomal daunorubicin at both 80 and 100 mg/m2, total daunorubicin concentrations in leukaemic cells were at least similar to those observed for free daunorubicin, and significant accumulation was also observed in bone marrow blast cells. Nineteen of 23 patients obtained a complete remission, although 13 had P-glycoprotein-overexpressing blast cells. Grade 3-4 mucositis was found only in three patients with very high AUCs for total daunorubicin and daunorubicinol. Conclusions: Liposomal daunorubicin at both 80 and 100 mg/m2 in combination with cytarabine may represent a valid treatment for high-risk acute leukaemia. Liposomal daunorubicin may be helpful in overcoming multidrug resistance, since it shows significant accumulation into tumour target cells, irrespective of P-glycoprotein expression. The tolerability profile suggests that toxicity may be related to exposure to both the parent drug and the metabolite.
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U2 - 10.2165/00003088-200342090-00004
DO - 10.2165/00003088-200342090-00004
M3 - Article
VL - 42
SP - 851
EP - 862
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
SN - 0312-5963
IS - 9
ER -