Disruption of calcium homeostasis and arrhythmogenesis induced by mutations in the cardiac ryanodine receptor and calsequestrin

Research output: Contribution to journalArticle

Abstract

Development of cardiac arrhythmias in several degenerative cardiac disorders such as heart failure is precipitated by abnormalities in intracellular calcium regulation. Recently, the identification of mutations in proteins responsible for the control of intracellular calcium has been associated with an inherited arrhythmogenic syndrome called catecholaminergic polymorphic ventricular tachycardia (CPVT). Here, we review the current knowledge about the molecular pathophysiology of CPVT and we discuss some potentially innovative strategies for controlling calcium-handling abnormalities in CPVT that may provide novel therapeutic options for affected patients. Published on behalf of the European Society of Cardiology. All rights reserved.

Original languageEnglish
Pages (from-to)293-301
Number of pages9
JournalCardiovascular Research
Volume77
Issue number2
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Calcium (cellular)
  • E-c coupling
  • SR (function)
  • Sudden death
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Disruption of calcium homeostasis and arrhythmogenesis induced by mutations in the cardiac ryanodine receptor and calsequestrin'. Together they form a unique fingerprint.

  • Cite this