Disruption of posteromedial large-scale neural communication predicts recovery from coma

Stein Silva, Francesco De Pasquale, Corine Vuillaume, Beatrice Riu, Isabelle Loubinoux, Thomas Geeraerts, Thierry Seguin, Vincent Bounes, Olivier Fourcade, Jean Francois Demonet, Patrice Peran

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We hypothesize that the major consciousness deficit observed in coma is due to the breakdown of long-range neuronal communication supported by precuneus and posterior cingulate cortex (PCC), and that prognosis depends on a specific connectivity pattern in these networks. Methods: We compared 27 prospectively recruited comatose patients who had severe brain injury (Glasgow Coma Scale score

Original languageEnglish
Pages (from-to)2036-2044
Number of pages9
JournalNeurology
Volume85
Issue number23
DOIs
Publication statusPublished - Dec 8 2015

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Coma
Communication
Parietal Lobe
Glasgow Coma Scale
Gyrus Cinguli
Consciousness
Brain Injuries

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Silva, S., De Pasquale, F., Vuillaume, C., Riu, B., Loubinoux, I., Geeraerts, T., ... Peran, P. (2015). Disruption of posteromedial large-scale neural communication predicts recovery from coma. Neurology, 85(23), 2036-2044. https://doi.org/10.1212/WNL.0000000000002196

Disruption of posteromedial large-scale neural communication predicts recovery from coma. / Silva, Stein; De Pasquale, Francesco; Vuillaume, Corine; Riu, Beatrice; Loubinoux, Isabelle; Geeraerts, Thomas; Seguin, Thierry; Bounes, Vincent; Fourcade, Olivier; Demonet, Jean Francois; Peran, Patrice.

In: Neurology, Vol. 85, No. 23, 08.12.2015, p. 2036-2044.

Research output: Contribution to journalArticle

Silva, S, De Pasquale, F, Vuillaume, C, Riu, B, Loubinoux, I, Geeraerts, T, Seguin, T, Bounes, V, Fourcade, O, Demonet, JF & Peran, P 2015, 'Disruption of posteromedial large-scale neural communication predicts recovery from coma', Neurology, vol. 85, no. 23, pp. 2036-2044. https://doi.org/10.1212/WNL.0000000000002196
Silva S, De Pasquale F, Vuillaume C, Riu B, Loubinoux I, Geeraerts T et al. Disruption of posteromedial large-scale neural communication predicts recovery from coma. Neurology. 2015 Dec 8;85(23):2036-2044. https://doi.org/10.1212/WNL.0000000000002196
Silva, Stein ; De Pasquale, Francesco ; Vuillaume, Corine ; Riu, Beatrice ; Loubinoux, Isabelle ; Geeraerts, Thomas ; Seguin, Thierry ; Bounes, Vincent ; Fourcade, Olivier ; Demonet, Jean Francois ; Peran, Patrice. / Disruption of posteromedial large-scale neural communication predicts recovery from coma. In: Neurology. 2015 ; Vol. 85, No. 23. pp. 2036-2044.
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