Disruption of posteromedial large-scale neural communication predicts recovery from coma

Stein Silva, Francesco De Pasquale, Corine Vuillaume, Beatrice Riu, Isabelle Loubinoux, Thomas Geeraerts, Thierry Seguin, Vincent Bounes, Olivier Fourcade, Jean Francois Demonet, Patrice Peran

Research output: Contribution to journalArticle

Abstract

We hypothesize that the major consciousness deficit observed in coma is due to the breakdown of long-range neuronal communication supported by precuneus and posterior cingulate cortex (PCC), and that prognosis depends on a specific connectivity pattern in these networks. Methods: We compared 27 prospectively recruited comatose patients who had severe brain injury (Glasgow Coma Scale score

Original languageEnglish
Pages (from-to)2036-2044
Number of pages9
JournalNeurology
Volume85
Issue number23
DOIs
Publication statusPublished - Dec 8 2015

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ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Silva, S., De Pasquale, F., Vuillaume, C., Riu, B., Loubinoux, I., Geeraerts, T., Seguin, T., Bounes, V., Fourcade, O., Demonet, J. F., & Peran, P. (2015). Disruption of posteromedial large-scale neural communication predicts recovery from coma. Neurology, 85(23), 2036-2044. https://doi.org/10.1212/WNL.0000000000002196