Abstract
This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.
| Original language | English |
|---|---|
| Pages (from-to) | 524-527 |
| Number of pages | 4 |
| Journal | Headache |
| Volume | 33 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1993 |
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Keywords
- cytokines
- diet
- migraine
- neuroimmune network
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Disruption of the immunopeptidergic network in dietary migraine. / Martelletti, P.; Stirparo, G.; Rinaldi, C.; Frati, L.; Giacovazzo, M.
In: Headache, Vol. 33, No. 10, 1993, p. 524-527.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Disruption of the immunopeptidergic network in dietary migraine
AU - Martelletti, P.
AU - Stirparo, G.
AU - Rinaldi, C.
AU - Frati, L.
AU - Giacovazzo, M.
PY - 1993
Y1 - 1993
N2 - This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.
AB - This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.
KW - cytokines
KW - diet
KW - migraine
KW - neuroimmune network
UR - http://www.scopus.com/inward/record.url?scp=0027380979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027380979&partnerID=8YFLogxK
U2 - 10.1111/j.1526-4610.1993.hed3310524.x
DO - 10.1111/j.1526-4610.1993.hed3310524.x
M3 - Article
C2 - 8294190
AN - SCOPUS:0027380979
VL - 33
SP - 524
EP - 527
JO - Headache
JF - Headache
SN - 0017-8748
IS - 10
ER -