Disruption of the immunopeptidergic network in dietary migraine

P. Martelletti; G. Stirparo; C. Rinaldi; L. Frati; M. Giacovazzo

doi:10.1111/j.1526-4610.1993.hed3310524.x

Disruption of the immunopeptidergic network in dietary migraine

P. Martelletti, G. Stirparo, C. Rinaldi, L. Frati, M. Giacovazzo

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Abstract

This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.

Original language	English
Pages (from-to)	524-527
Number of pages	4
Journal	Headache
Volume	33
Issue number	10
DOIs	https://doi.org/10.1111/j.1526-4610.1993.hed3310524.x
Publication status	Published - 1993

Keywords

cytokines
diet
migraine
neuroimmune network

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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10.1111/j.1526-4610.1993.hed3310524.x

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AU - Stirparo, G.

AU - Rinaldi, C.

AU - Frati, L.

AU - Giacovazzo, M.

PY - 1993

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Disruption of the immunopeptidergic network in dietary migraine

Abstract

Keywords

ASJC Scopus subject areas

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