Disruption of the immunopeptidergic network in dietary migraine

P. Martelletti, G. Stirparo, C. Rinaldi, L. Frati, M. Giacovazzo

Research output: Contribution to journalArticlepeer-review


This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.

Original languageEnglish
Pages (from-to)524-527
Number of pages4
Issue number10
Publication statusPublished - 1993


  • cytokines
  • diet
  • migraine
  • neuroimmune network

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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