Disruption of the immunopeptidergic network in dietary migraine

P. Martelletti; G. Stirparo; C. Rinaldi; L. Frati; M. Giacovazzo

doi:10.1111/j.1526-4610.1993.hed3310524.x

Disruption of the immunopeptidergic network in dietary migraine

P. Martelletti, G. Stirparo, C. Rinaldi, L. Frati, M. Giacovazzo

www.neuromed.it

Research output: Contribution to journal › Article

Abstract

This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.

Original language	English
Pages (from-to)	524-527
Number of pages	4
Journal	Headache
Volume	33
Issue number	10
DOIs	https://doi.org/10.1111/j.1526-4610.1993.hed3310524.x
Publication status	Published - 1993

Keywords

cytokines
diet
migraine
neuroimmune network

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

Access to Document

10.1111/j.1526-4610.1993.hed3310524.x

Fingerprint Dive into the research topics of 'Disruption of the immunopeptidergic network in dietary migraine'. Together they form a unique fingerprint.

Cite this

Martelletti, P., Stirparo, G., Rinaldi, C., Frati, L., & Giacovazzo, M. (1993). Disruption of the immunopeptidergic network in dietary migraine. Headache, 33(10), 524-527. https://doi.org/10.1111/j.1526-4610.1993.hed3310524.x

@article{4e62ca6f28cb4a959a5ad0fa5971b9cb,

title = "Disruption of the immunopeptidergic network in dietary migraine",

abstract = "This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.",

keywords = "cytokines, diet, migraine, neuroimmune network",

author = "P. Martelletti and G. Stirparo and C. Rinaldi and L. Frati and M. Giacovazzo",

year = "1993",

doi = "10.1111/j.1526-4610.1993.hed3310524.x",

language = "English",

volume = "33",

pages = "524--527",

journal = "Headache",

issn = "0017-8748",

publisher = "wiley",

number = "10",

}

TY - JOUR

T1 - Disruption of the immunopeptidergic network in dietary migraine

AU - Martelletti, P.

AU - Stirparo, G.

AU - Rinaldi, C.

AU - Frati, L.

AU - Giacovazzo, M.

PY - 1993

Y1 - 1993

N2 - This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.

AB - This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.

KW - cytokines

KW - diet

KW - migraine

KW - neuroimmune network

UR - http://www.scopus.com/inward/record.url?scp=0027380979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027380979&partnerID=8YFLogxK

U2 - 10.1111/j.1526-4610.1993.hed3310524.x

DO - 10.1111/j.1526-4610.1993.hed3310524.x

M3 - Article

C2 - 8294190

AN - SCOPUS:0027380979

VL - 33

SP - 524

EP - 527

JO - Headache

JF - Headache

SN - 0017-8748

IS - 10

ER -