Dissecting pulmonary large-cell carcinoma by targeted next generation sequencing of several cancer genes pushes genotypic-phenotypic correlations to emerge

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13 Citations (Scopus)

Abstract

Introduction: Little is known about genotypic and phenotypic correlations in undifferentiated large-cell carcinoma (LCC) of the lung. Methods: Thirty LCC were dissected by unsupervised targeted next generation sequencing analysis for 50 cancer-associated oncogenes and tumor suppressor genes. Cell differentiation lineages were unveiled by using thyroid transcription factor-1 (TTF1) for adenocarcinoma (ADC) and p40 for squamous cell carcinoma (SQC), dichotomizing immunohistochemistry (IHC) results for TTF1 as negative or positive (whatever its extent) and for p40 as negative, positive, or focal (if

Original languageEnglish
Pages (from-to)1560-1569
Number of pages10
JournalJournal of Thoracic Oncology
Volume10
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

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Large Cell Carcinoma
Neoplasm Genes
Lung
Cell Lineage
Tumor Suppressor Genes
Oncogenes
Cell Differentiation
Squamous Cell Carcinoma
Adenocarcinoma
Immunohistochemistry
Neoplasms
adjuvant P40
thyroid nuclear factor 1

Keywords

  • Immunohistochemistry
  • Large-cell carcinoma
  • Lung
  • p40
  • Targeted next generation sequencing
  • TTF1

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

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title = "Dissecting pulmonary large-cell carcinoma by targeted next generation sequencing of several cancer genes pushes genotypic-phenotypic correlations to emerge",
abstract = "Introduction: Little is known about genotypic and phenotypic correlations in undifferentiated large-cell carcinoma (LCC) of the lung. Methods: Thirty LCC were dissected by unsupervised targeted next generation sequencing analysis for 50 cancer-associated oncogenes and tumor suppressor genes. Cell differentiation lineages were unveiled by using thyroid transcription factor-1 (TTF1) for adenocarcinoma (ADC) and p40 for squamous cell carcinoma (SQC), dichotomizing immunohistochemistry (IHC) results for TTF1 as negative or positive (whatever its extent) and for p40 as negative, positive, or focal (if",
keywords = "Immunohistochemistry, Large-cell carcinoma, Lung, p40, Targeted next generation sequencing, TTF1",
author = "Giuseppe Pelosi and Alessandra Fabbri and Mauro Papotti and Giulio Rossi and Alberto Cavazza and Luisella Righi and Elena Tamborini and Federica Perrone and Giulio Settanni and Adele Busico and Testi, {Maria Adele} and Patrick Maisonneuve and {De Braud}, Filippo and Marina Garassino and Barbara Valeri and Angelica Sonzogni and Ugo Pastorino",
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T1 - Dissecting pulmonary large-cell carcinoma by targeted next generation sequencing of several cancer genes pushes genotypic-phenotypic correlations to emerge

AU - Pelosi, Giuseppe

AU - Fabbri, Alessandra

AU - Papotti, Mauro

AU - Rossi, Giulio

AU - Cavazza, Alberto

AU - Righi, Luisella

AU - Tamborini, Elena

AU - Perrone, Federica

AU - Settanni, Giulio

AU - Busico, Adele

AU - Testi, Maria Adele

AU - Maisonneuve, Patrick

AU - De Braud, Filippo

AU - Garassino, Marina

AU - Valeri, Barbara

AU - Sonzogni, Angelica

AU - Pastorino, Ugo

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Introduction: Little is known about genotypic and phenotypic correlations in undifferentiated large-cell carcinoma (LCC) of the lung. Methods: Thirty LCC were dissected by unsupervised targeted next generation sequencing analysis for 50 cancer-associated oncogenes and tumor suppressor genes. Cell differentiation lineages were unveiled by using thyroid transcription factor-1 (TTF1) for adenocarcinoma (ADC) and p40 for squamous cell carcinoma (SQC), dichotomizing immunohistochemistry (IHC) results for TTF1 as negative or positive (whatever its extent) and for p40 as negative, positive, or focal (if

AB - Introduction: Little is known about genotypic and phenotypic correlations in undifferentiated large-cell carcinoma (LCC) of the lung. Methods: Thirty LCC were dissected by unsupervised targeted next generation sequencing analysis for 50 cancer-associated oncogenes and tumor suppressor genes. Cell differentiation lineages were unveiled by using thyroid transcription factor-1 (TTF1) for adenocarcinoma (ADC) and p40 for squamous cell carcinoma (SQC), dichotomizing immunohistochemistry (IHC) results for TTF1 as negative or positive (whatever its extent) and for p40 as negative, positive, or focal (if

KW - Immunohistochemistry

KW - Large-cell carcinoma

KW - Lung

KW - p40

KW - Targeted next generation sequencing

KW - TTF1

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