Dissecting pulmonary large-cell carcinoma by targeted next generation sequencing of several cancer genes pushes genotypic-phenotypic correlations to emerge

Research output: Contribution to journalArticle

Abstract

Introduction: Little is known about genotypic and phenotypic correlations in undifferentiated large-cell carcinoma (LCC) of the lung. Methods: Thirty LCC were dissected by unsupervised targeted next generation sequencing analysis for 50 cancer-associated oncogenes and tumor suppressor genes. Cell differentiation lineages were unveiled by using thyroid transcription factor-1 (TTF1) for adenocarcinoma (ADC) and p40 for squamous cell carcinoma (SQC), dichotomizing immunohistochemistry (IHC) results for TTF1 as negative or positive (whatever its extent) and for p40 as negative, positive, or focal (if

Original languageEnglish
Pages (from-to)1560-1569
Number of pages10
JournalJournal of Thoracic Oncology
Volume10
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • Immunohistochemistry
  • Large-cell carcinoma
  • Lung
  • p40
  • Targeted next generation sequencing
  • TTF1

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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