Dissecting the roles of thymoquinone on the prevention and the treatment of hepatocellular carcinoma: An overview on the current state of knowledge

Sabrina Bimonte, Vittorio Albino, Antonio Barbieri, Maria Luisa Tamma, Aurelio Nasto, Raffaele Palaia, Carlo Molino, Paolo Bianco, Andrea Vitale, Rita Schiano, Aldo Giudice, Marco Cascella

Research output: Contribution to journalReview article

Abstract

Thymoquinone (TQ) is the principal active monomer isolated from the seed of the medicinal plant Nigella sativa. This compound has antitumor effects against various types of cancer including hepatocellular carcinoma (HCC), mainly due to its anti-inflammatory and anti-oxidant properties. Several pre-clinical studies showed that TQ, through the modulation of different molecular pathways, is able to induce anti-apoptotic and anti-proliferative effects in HCC, without signs of toxicity. Moreover, it has been suggested that TQ has hepatoprotective effects by enhancing the tolerability and effectivity of neoadjuvant therapy prior to liver surgery, although the underlying mechanisms are not completely understood. Based on these findings, is assumable that TQ could represent a valuable therapeutic option for patients suffering from HCC. In this review, we summarize the potential roles of TQ in the prevention and treatment of HCC, by revising the preclinical studies and by highlighting the potential applications of TQ as a therapeutic choice for HCC treatment into clinical practices.

Original languageEnglish
Article number10
JournalInfectious Agents and Cancer
Volume14
Issue number1
DOIs
Publication statusPublished - Apr 16 2019

Fingerprint

Hepatocellular Carcinoma
Therapeutics
Nigella sativa
Neoadjuvant Therapy
Medicinal Plants
Oxidants
thymoquinone
Seeds
Anti-Inflammatory Agents
Liver
Neoplasms

Keywords

  • Cell apoptosis
  • Cell proliferation
  • Hepatocellular carcinoma
  • Nigella sativa
  • Thymoquinone

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Infectious Diseases
  • Cancer Research

Cite this

Dissecting the roles of thymoquinone on the prevention and the treatment of hepatocellular carcinoma : An overview on the current state of knowledge. / Bimonte, Sabrina; Albino, Vittorio; Barbieri, Antonio; Tamma, Maria Luisa; Nasto, Aurelio; Palaia, Raffaele; Molino, Carlo; Bianco, Paolo; Vitale, Andrea; Schiano, Rita; Giudice, Aldo; Cascella, Marco.

In: Infectious Agents and Cancer, Vol. 14, No. 1, 10, 16.04.2019.

Research output: Contribution to journalReview article

Bimonte, Sabrina ; Albino, Vittorio ; Barbieri, Antonio ; Tamma, Maria Luisa ; Nasto, Aurelio ; Palaia, Raffaele ; Molino, Carlo ; Bianco, Paolo ; Vitale, Andrea ; Schiano, Rita ; Giudice, Aldo ; Cascella, Marco. / Dissecting the roles of thymoquinone on the prevention and the treatment of hepatocellular carcinoma : An overview on the current state of knowledge. In: Infectious Agents and Cancer. 2019 ; Vol. 14, No. 1.
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