Dissecting trafficking and signaling of atypical chemokine receptors

Elena Borroni, Cinzia Cancellieri, Massimo Locati, Raffaella Bonecchi

Research output: Chapter in Book/Report/Conference proceedingChapter


Atypical chemokine receptors are a distinct subset of chemokine receptors able to modulate immune responses by acting as chemokine decoy/scavengers or transporters. Intracellular trafficking properties sustained by Gαi-independent signaling have emerged as a major determinant of their biological properties, which support continuous uptake, transport, and/or concentration, of the ligands. Here, we are providing methods to study both trafficking and signaling of this class of chemokine receptors focusing on the atypical chemokine receptor D6 that degrades inflammatory CC chemokines.

Original languageEnglish
Title of host publicationMethods in Enzymology
Number of pages18
Publication statusPublished - 2013

Publication series

NameMethods in Enzymology
ISSN (Print)00766879
ISSN (Electronic)15577988


  • β-Arrestin
  • Atypical chemokine receptors
  • Chemokine
  • GPCR signaling
  • GPCR trafficking

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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