Disseminated Burkitt's lymphoma after kidney transplantation: A case report in a boy with Drash syndrome

A. Ferrari, D. Perotti, R. Giardini, L. Ghio, S. Riva, M. Massimino

Research output: Contribution to journalArticle

Abstract

Purpose. We discuss the clinical, laboratory findings and treatment of a boy who developed Burkitt's lymphoma (BL) after renal transplant and some issues about lymphoproliferative disorders after transplantation. Methods. A 6-year-old boy with Drash syndrome developed disseminated Burkitt's lymphoma 38 months after transplantation for renal failure. Immunosuppressive therapy had consisted of prednisolone and cyclosporine. Polychemotherapy was initiated. Results. Polychemotherapy induced rapid and complete remission of the disease without major side effects despite the renal transplant allograft and prolonged immunosuppression. Conclusions. A child with posttransplantation B-cell high-grade lymphoma can be successfully treated with the same chemotherapy regimen used for ordinary cases.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Volume19
Issue number2
DOIs
Publication statusPublished - Mar 1997

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Denys-Drash Syndrome
Burkitt Lymphoma
Combination Drug Therapy
Kidney Transplantation
Transplantation
Transplants
Kidney
Lymphoproliferative Disorders
B-Cell Lymphoma
Immunosuppressive Agents
Prednisolone
Non-Hodgkin's Lymphoma
Immunosuppression
Cyclosporine
Renal Insufficiency
Allografts
Drug Therapy
Therapeutics

Keywords

  • Burkitt's lymphoma
  • Drash syndrome
  • Posttransplantation malignancies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

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abstract = "Purpose. We discuss the clinical, laboratory findings and treatment of a boy who developed Burkitt's lymphoma (BL) after renal transplant and some issues about lymphoproliferative disorders after transplantation. Methods. A 6-year-old boy with Drash syndrome developed disseminated Burkitt's lymphoma 38 months after transplantation for renal failure. Immunosuppressive therapy had consisted of prednisolone and cyclosporine. Polychemotherapy was initiated. Results. Polychemotherapy induced rapid and complete remission of the disease without major side effects despite the renal transplant allograft and prolonged immunosuppression. Conclusions. A child with posttransplantation B-cell high-grade lymphoma can be successfully treated with the same chemotherapy regimen used for ordinary cases.",
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AU - Perotti, D.

AU - Giardini, R.

AU - Ghio, L.

AU - Riva, S.

AU - Massimino, M.

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AB - Purpose. We discuss the clinical, laboratory findings and treatment of a boy who developed Burkitt's lymphoma (BL) after renal transplant and some issues about lymphoproliferative disorders after transplantation. Methods. A 6-year-old boy with Drash syndrome developed disseminated Burkitt's lymphoma 38 months after transplantation for renal failure. Immunosuppressive therapy had consisted of prednisolone and cyclosporine. Polychemotherapy was initiated. Results. Polychemotherapy induced rapid and complete remission of the disease without major side effects despite the renal transplant allograft and prolonged immunosuppression. Conclusions. A child with posttransplantation B-cell high-grade lymphoma can be successfully treated with the same chemotherapy regimen used for ordinary cases.

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