Disseminated granuloma annulare: Efficacy of cyclosporine therapy

S. Spadino, A. Altomare, G. Cainelli, C. Franchi, E. Frigerio, C. Garutti, M. Taglioni, G. F. Altomare

Research output: Contribution to journalArticle

Abstract

Granuloma annulare is an anatomo-clinical entity that is frequently encountered in everyday dermatological practice. We report our experience regarding 4 patients with disseminated granuloma annulare. Each patient was treated with a cycle of cyclosporine therapy for six weeks. A cycle of systemic cyclosporine therapy was started at a dose of 4 mg/kg/day for four weeks, subsequently reduced by 0.5 mg/kg/day every two weeks. The clinical picture more or less completely resolved within three weeks in all of the patients, and there were no relapses during the dose-tapering period or the following 12 months. Cyclosporine was optimally tolerated by all four patients, none of whom experienced any therapy-related side effects. Cyclosporine is a valid therapeutic option for the treatment of disseminated granuloma annulare, although we recommend its use in a protected hospital environment that facilitates patient monitoring.

Original languageEnglish
Pages (from-to)433-438
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Volume19
Issue number2
Publication statusPublished - Apr 2006

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Granuloma Annulare
Cyclosporine
Therapeutics
Physiologic Monitoring
Recurrence

Keywords

  • Cyclosporine
  • Granuloma annulare

ASJC Scopus subject areas

  • Pharmacology

Cite this

Spadino, S., Altomare, A., Cainelli, G., Franchi, C., Frigerio, E., Garutti, C., ... Altomare, G. F. (2006). Disseminated granuloma annulare: Efficacy of cyclosporine therapy. International Journal of Immunopathology and Pharmacology, 19(2), 433-438.

Disseminated granuloma annulare : Efficacy of cyclosporine therapy. / Spadino, S.; Altomare, A.; Cainelli, G.; Franchi, C.; Frigerio, E.; Garutti, C.; Taglioni, M.; Altomare, G. F.

In: International Journal of Immunopathology and Pharmacology, Vol. 19, No. 2, 04.2006, p. 433-438.

Research output: Contribution to journalArticle

Spadino, S, Altomare, A, Cainelli, G, Franchi, C, Frigerio, E, Garutti, C, Taglioni, M & Altomare, GF 2006, 'Disseminated granuloma annulare: Efficacy of cyclosporine therapy', International Journal of Immunopathology and Pharmacology, vol. 19, no. 2, pp. 433-438.
Spadino S, Altomare A, Cainelli G, Franchi C, Frigerio E, Garutti C et al. Disseminated granuloma annulare: Efficacy of cyclosporine therapy. International Journal of Immunopathology and Pharmacology. 2006 Apr;19(2):433-438.
Spadino, S. ; Altomare, A. ; Cainelli, G. ; Franchi, C. ; Frigerio, E. ; Garutti, C. ; Taglioni, M. ; Altomare, G. F. / Disseminated granuloma annulare : Efficacy of cyclosporine therapy. In: International Journal of Immunopathology and Pharmacology. 2006 ; Vol. 19, No. 2. pp. 433-438.
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