Disseminated granuloma annulare: Efficacy of cyclosporine therapy

S. Spadino, A. Altomare, G. Cainelli, C. Franchi, E. Frigerio, C. Garutti, M. Taglioni, G. F. Altomare

Research output: Contribution to journalArticlepeer-review


Granuloma annulare is an anatomo-clinical entity that is frequently encountered in everyday dermatological practice. We report our experience regarding 4 patients with disseminated granuloma annulare. Each patient was treated with a cycle of cyclosporine therapy for six weeks. A cycle of systemic cyclosporine therapy was started at a dose of 4 mg/kg/day for four weeks, subsequently reduced by 0.5 mg/kg/day every two weeks. The clinical picture more or less completely resolved within three weeks in all of the patients, and there were no relapses during the dose-tapering period or the following 12 months. Cyclosporine was optimally tolerated by all four patients, none of whom experienced any therapy-related side effects. Cyclosporine is a valid therapeutic option for the treatment of disseminated granuloma annulare, although we recommend its use in a protected hospital environment that facilitates patient monitoring.

Original languageEnglish
Pages (from-to)433-438
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Issue number2
Publication statusPublished - Apr 2006


  • Cyclosporine
  • Granuloma annulare

ASJC Scopus subject areas

  • Pharmacology


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